hydroxymuconic semialdehyde

Base Information

• Chemical Name: hydroxymuconic semialdehyde
• CAS No.: 3270-98-2
• Molecular Formula: C6H6 O4
• Molecular Weight: 142.111
• Hs Code.: 2918990090
• Mol file: 3270-98-2.mol

Synonyms:2,4-Pentadienoicacid, 5-formyl-2-hydroxy- (7CI,8CI); Muconaldehydic acid, 2-hydroxy- (6CI);2-Hydroxymuconic acid 6-semialdehyde; 2-Hydroxymuconic semialdehyde; a-Hydroxymuconic semialdehyde; a-Hydroxymuconic e-semialdehyde

Chemical Property of hydroxymuconic semialdehyde

Chemical Property:

• Vapor Pressure: 0.00098mmHg at 25°C
• Boiling Point: 280.8°C at 760 mmHg
• Flash Point: 137.9°C
• PSA: 74.60000
• Density: 1.365g/cm³
• LogP: 0.26800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hydroxymuconic semialdehyde

There total 4 articles about hydroxymuconic semialdehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 2-hydroxy-6-oxohexa-2,4-dienoic acid (3270-98-2)

Guidance literature:

With catechol-2,3-dioxygenase; In aq. phosphate buffer; pH=7; Enzymatic reaction;

DOI:10.1021/jacs.5b07055

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → secopyrocatechol (3270-98-2,77934-57-7)

Guidance literature:

In water; at 4 ℃; for 3.5h; enzymatic synthesis (enzyme from red skin of Amanita muscaria L_.);

DOI:10.1002/hlca.19910740115

Reference yield:

2H-pyran-2-one-6-carboxylic acid (672-67-3) → 1-Hydroxy-4-formyl-1-carboxy-3cis.1trans-butadien (3270-98-2,77934-57-7)

Guidance literature:

Multistep reaction; (i) LiAlH₄, (ii) aq. H₂SO₄;

upstream raw materials:

2H-pyran-2-one-6-carboxylic acid

benzene-1,2-diol

2-amino-3-carboxymuconic acid 6-semialdehyde

Downstream raw materials:

formic acid

2-hydroxy-2,4-pentadienoic acid

Refernces

• 1、 Milligan, Sierra,Wang, Jian,Yan, Yajun,Zhang, Ruihua. "Microbial utilization of lignin-derived aromatics: Via a synthetic catechol meta -cleavage pathway". . p. 8238 - 8250. Retrieved 2021/11/01.
• 2、 Davis, Ian,Yang, Yu,Wherritt, Daniel,Liu, Aimin. "Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism". . p. 9594 - 9603. Retrieved 2018/06/29.