N,N-Dimethylformamide dimethyl acetal

Base Information

• Chemical Name: N,N-Dimethylformamide dimethyl acetal
• CAS No.: 4637-24-5
• Deprecated CAS: 637765-94-7
• Molecular Formula: C5H13NO2
• Molecular Weight: 119.164
• Hs Code.: 29225000
• European Community (EC) Number: 225-063-3
• UNII: DF7CTT5QPH
• DSSTox Substance ID: DTXSID3063540
• Nikkaji Number: J24.180F
• Wikidata: Q27158310
• Mol file: 4637-24-5.mol

Synonyms:dimethylformamide-dimethylacetal;dimethylformamide-dimethylacetal, 13C-labeled;dimethylformamide-dimethylacetal, 14C-labeled;DMF-DMA

Chemical Property of N,N-Dimethylformamide dimethyl acetal

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 31.1mmHg at 25°C
• Melting Point: -85 °C
• Refractive Index: n20/D 1.396(lit.)
• Boiling Point: 104.3 °C at 760 mmHg
• PKA: 5.00±0.50(Predicted)
• Flash Point: 7.2 °C
• PSA: 21.70000
• Density: 0.906 g/cm³
• LogP: 0.12440
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Solubility.: Miscible with most organic solvents.
• Water Solubility.: hydrolysis
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 119.094628657
• Heavy Atom Count: 8
• Complexity: 52.4

Purity/Quality:

99.0% ^*data from raw suppliers

1,1-Dimethoxy-N,N-dimethylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, Xn, Xi
• Hazard Codes: F,Xn,Xi
• Statements: 11-22-36/37/38-36/38-20-20/21/22-10-52
• Safety Statements: 16-26-36/37-36/37/39-33-29-7/9

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: CN(C)C(OC)OC
• Uses: 1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes. N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates. Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Technology Process of N,N-Dimethylformamide dimethyl acetal

There total 15 articles about N,N-Dimethylformamide dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + dimethyl sulfate (77-78-1) → N,N-dimethyl-formamide dimethyl acetal (4637-24-5)

Guidance literature:

With nitrogen; at 80 ℃; for 2h;

DOI:10.1016/0022-328X(89)85018-1

Reference yield: 95.0%

dimethyl amine (124-40-3) + trimethyl orthoformate (149-73-5) → N,N-dimethyl-formamide dimethyl acetal (4637-24-5)

Guidance literature:

With acetyl chloride; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 86.8%

chloro-dimethoxy-methane (52117-32-5) + dimethyl amine (124-40-3) → N,N-dimethyl-formamide dimethyl acetal (4637-24-5)

Guidance literature:

at 140 - 150 ℃; for 2h; Green chemistry;

upstream raw materials:

N,N-dimethyl-formamide

dimethyl sulfate

chloroform

sodium methylate

Downstream raw materials:

3-(Dimethylamino)-1,2-diphenyl-2-propen-1-on

N,N-dimethyl-N'-(5-phenyl-[1,3,4]selenadiazol-2-yl)-formamidine

N,N-dimethylformamide dipropyl acetal

2-dimethylaminomethylene-3-oxo-butyric acid methyl ester

Refernces

• 1、 -. "Environment-friendly preparation method of N,N-dimethylformamide dimethylacetal". Paragraph 0026-0045. . Retrieved 2019/07/29.
• 2、 -. "Novel process for preparing 4,4-difluoro-((2-dialkylamino) methylene)-3-oxobutanic acid alkyl ester". Paragraph 0053. . Retrieved 2017/01/31.