Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: acetic acid / 1 h / 60 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 4 h / 20 °C / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 90 °C / Inert atmosphere
6.1: tris-(dibenzylideneacetone)dipalladium(0); XPhos; sodium hydrogencarbonate / water; 1,4-dioxane / 12 h / 90 °C / Inert atmosphere
6.2: Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; XPhos;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;