N-BOC-piperidine-4-carboxylic acid

Base Information

• Chemical Name: N-BOC-piperidine-4-carboxylic acid
• CAS No.: 84358-13-4
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Hs Code.: 29339900
• Mol file: 84358-13-4.mol

Synonyms:1-tert-butoxycarbonylpiperidine-4-carboxylic acid;1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid;1-Boc-piperidine-4-carboxylic acid;Piperidine-1,4-dicarboxylic Acid mono-tert-butyl ester;1-BOC-4-piperidine carboxylic acid;Boc-Piperidine-4-carboxylic acid;Boc-isonipecotic acid;1-N-Boc-Piperidine-4-carboxylic acid;N-tert-butoxycarbonyl-4-piperidinecarboxylic acid;Piperidine-4-carboxylic acid, N-BOC protected;1-Boc-piperidine-4-carboxylicacid;Boc-Pic(4)-OH;1-Boc-piperidine-4-carboxylic acid, 98%;1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid;1-tert-butoxycarbonylpiperidine-4-carboxylate;

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Chemical Property of N-BOC-piperidine-4-carboxylic acid

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 6.15E-06mmHg at 25°C
• Melting Point: 148-153 °C
• Boiling Point: 353.2 °C at 760 mmHg
• PKA: 4.56±0.20(Predicted)
• Flash Point: 167.4 °C
• PSA: 66.84000
• Density: 1.164 g/cm³
• LogP: 1.65600
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is a pharmaceutical intermediate. he camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

Technology Process of N-BOC-piperidine-4-carboxylic acid

There total 2 articles about N-BOC-piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-bromo-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1146955-04-5) + 2-bromobenzylzinc(II) bromide (307496-27-1) → 4-[(2-bromophenyl)methyl]-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid + 1-[(tert-butoxy)carbonyl]-1,2,3,6-tetrahydropyridine-4-carboxylic acid (70684-84-3) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8)

Guidance literature:

With 1,2-bis-(diphenylphosphino)ethane; cobalt(II) bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃; for 1h;

DOI:10.1039/d0cc02734k

Reference yield:

→ N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) + tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

Reference yield: 100.0%

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate (123855-51-6)

Guidance literature:

With borane-THF; In tetrahydrofuran;

DOI:10.1016/S0960-894X(01)00661-8 DOI:10.1016/j.bmcl.2003.12.006

upstream raw materials:

4-bromo-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

2-bromobenzylzinc(II) bromide

Downstream raw materials:

p-nitrophenyl 1-(tert-butoxycarbonyl)-4-piperidinecarboxylate

4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester

4-[3-(4-Chloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

4-[3-(4-Chloro-phenyl)-2-methyl-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants". . . Retrieved 2008/06/13.