(RS)-N-phthaloyl-p-nitrophenylalanine

Base Information

• Chemical Name: (RS)-N-phthaloyl-p-nitrophenylalanine
• CAS No.: 60666-01-5
• Molecular Formula: C₁₇H₁₂N₂O₆
• Molecular Weight: 340.292
• Mol file: 60666-01-5.mol

Synonyms:(RS)-N-phthaloyl-p-nitrophenylalanine

Chemical Property of (RS)-N-phthaloyl-p-nitrophenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-N-phthaloyl-p-nitrophenylalanine

There total 5 articles about (RS)-N-phthaloyl-p-nitrophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ (RS)-N-phthaloyl-p-nitrophenylalanine (60666-01-5,5467-31-2)

Guidance literature:

In acetonitrile; at 145 ℃; Sealed tube;

Reference yield: 93.0%

phthalic anhydride (85-44-9) + 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → (RS)-N-phthaloyl-p-nitrophenylalanine (60666-01-5,5467-31-2)

Guidance literature:

With triethylamine; In toluene; for 3h; Heating;

DOI:10.1016/0040-4020(96)00307-9

Reference yield:

N-(2-carboxy-benzoyl)-4-nitro-phenylalanine (101445-16-3) → (RS)-N-phthaloyl-p-nitrophenylalanine (60666-01-5,5467-31-2)

Guidance literature:

With acetic anhydride;

upstream raw materials:

phthalic anhydride

4-nitrophenylalanine

N-(2-carboxy-benzoyl)-4-nitro-phenylalanine

(4-nitro-benzyl)-phthalimido-malonic acid diethyl ester

Downstream raw materials:

3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide

N-phthalimido-4-nitro-L-phenylalanine ethyl ester

4-nitro-N,N-phthaloyl-D-phenylalanin-ethyl ester

N-tert-Butyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(4-nitro-phenyl)-propionamide

Refernces

• 1、 Miao, Jinmin,Yang, Ke,Kurek, Martin,Ge, Haibo. "Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)-H Bonds". supporting information. p. 3738 - 3741. Retrieved 2015/08/18.