4-nitrophenylalanine

Base Information

• Chemical Name: 4-nitrophenylalanine
• CAS No.: 1991-83-9
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.189
• Mol file: 1991-83-9.mol

Synonyms:

Chemical Property of 4-nitrophenylalanine

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-nitrophenylalanine

There total 29 articles about 4-nitrophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester (6265-87-8) → 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5)

Guidance literature:

With hydrogenchloride; acetic acid; In water; for 24h; Heating;

DOI:10.1021/jm070401q

Reference yield: 50.0%

H2 S(g) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5)

Guidance literature:

With nitric acid; In concentrated H₂ SO₄;

Reference yield: 24.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) + DL-2-nitrophenylalanine (1991-82-8,19883-75-1,35378-63-3)

Guidance literature:

With sulfuric acid; nitric acid; at -10 ℃; for 3.5h;

DOI:10.1021/jm00117a015

upstream raw materials:

2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester

formylamino-(4-nitro-benzyl)-malonic acid diethyl ester

Phenylalanine

(4-nitro-benzyl)-malonic acid

Downstream raw materials:

4-(4-nitro-benzyl)-oxazolidine-2,5-dione

(RS)-N-phthaloyl-p-nitrophenylalanine

N-formyl-4-nitro-phenylalanine

N-dichloroacetyl-4-nitro-phenylalanine

Refernces

• 1、 Shim, Eric Kian-Shiun,Lee, Soo-Ying. "Nitration of Tyrosine in the Mucin Glycoprotein of Edible Bird's Nest Changes Its Color from White to Red". . p. 5654 - 5662. Retrieved 2018.
• 2、 Parmeggiani, Fabio,Lovelock, Sarah L.,Weise, Nicholas J.,Ahmed, Syed T.,Turner, Nicholas J.. "Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process". . p. 4608 - 4611. Retrieved 2015/04/14.