C₁₈H₁₂FN₃

Base Information

• Chemical Name: C₁₈H₁₂FN₃
• CAS No.: 1353511-78-0
• Molecular Formula: C₁₈H₁₂FN₃
• Molecular Weight: 289.312
• Mol file: 1353511-78-0.mol

Synonyms:C₁₈H₁₂FN₃

Chemical Property of C₁₈H₁₂FN₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₂FN₃

There total 3 articles about C₁₈H₁₂FN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-Bromopyridine (626-55-1,163928-56-1) + 2-(4-fluorophenyl)imidazo[1,2-a]pyridine (347-12-6) → C18H12FN3 (1353511-78-0)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100 ℃; for 15h; Inert atmosphere; Sealed vessel;

DOI:10.1016/j.tetlet.2011.11.015

Reference yield:

imidazo[1,2-a]pyridin-2-yl trifluoromethanesulfonate (1021019-74-8) → C18H12FN3 (1353511-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere; Sealed vessel

2: palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid / N,N-dimethyl acetamide / 15 h / 100 °C / Inert atmosphere; Sealed vessel

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In 1,4-dioxane; N,N-dimethyl acetamide; water; 1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2011.11.015

Reference yield:

2-aminopyridine (504-29-0) → C18H12FN3 (1353511-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 18.5 h / 0 °C / Reflux

1.2: 12 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere; Sealed vessel

3.1: palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid / N,N-dimethyl acetamide / 15 h / 100 °C / Inert atmosphere; Sealed vessel

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; water; 2.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2011.11.015

upstream raw materials:

2-aminopyridine

3-Bromopyridine

2-(4-fluorophenyl)imidazo[1,2-a]pyridine

imidazo[1,2-a]pyridin-2-yl trifluoromethanesulfonate

Refernces

• 1、 Marhadour, Sophie,Marchand, Pascal,Pagniez, Fabrice,Bazin, Marc-Antoine,Picot, Carine,Lozach, Olivier,Ruchaud, Sandrine,Antoine, Maud,Meijer, Laurent,Rachidi, Najma,Le Pape, Patrice. "Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents". . p. 543 - 556. Retrieved 2013/02/23.