N^α-(4-benzoylbenzoyl)-L-biocytin

Base Information

• Chemical Name: N^α-(4-benzoylbenzoyl)-L-biocytin
• CAS No.: 165898-24-8
• Molecular Formula: C₃₀H₃₆N₄O₆S
• Molecular Weight: 580.705
• Mol file: 165898-24-8.mol

Synonyms:N^α-(4-benzoylbenzoyl)-L-biocytin

Chemical Property of N^α-(4-benzoylbenzoyl)-L-biocytin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(4-benzoylbenzoyl)-L-biocytin

There total 5 articles about N^α-(4-benzoylbenzoyl)-L-biocytin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-benzoylbenzoic acid N-hydroxysuccinimide ester (91990-88-4) + biocytin (576-19-2) → Nα-(4-benzoylbenzoyl)-L-biocytin (165898-24-8)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2009.12.019

Reference yield:

4-carboxybenzophenone (611-95-0) → Nα-(4-benzoylbenzoyl)-L-biocytin (165898-24-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

4: lithium hydroxide; water / methanol / 4 h / 0 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bioorg.2022.105674

Reference yield:

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → Nα-(4-benzoylbenzoyl)-L-biocytin (165898-24-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

4: lithium hydroxide; water / methanol / 4 h / 0 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bioorg.2022.105674

upstream raw materials:

p-benzoylbenzoic acid N-hydroxysuccinimide ester

biocytin

4-carboxybenzophenone

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

Downstream raw materials:

C₅₇H₇₉N₇O₈S

1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane

Refernces

• 1、 Duan, Hong-Quan,Gan, Chun-Chun,Jia, Miao,Jin, Mei-Na,Liu, Xin-Qi,Peng, Li-Yuan,Qin, Nan,Wu, Xiao-Ran,Zhang, Pan,Zhu, Wen. "Target identification of anti-diabetic and anti-obesity flavonoid derivative (Fla-CN)". . . Retrieved 2022/02/19.