N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate

Base Information

• Chemical Name: N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate
• CAS No.: 1187317-72-1
• Molecular Formula: C₂HF₃O₂*C₁₇H₁₆N₄O
• Molecular Weight: 406.364
• Mol file: 1187317-72-1.mol

Synonyms:N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate

Chemical Property of N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate

There total 8 articles about N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2,4-dimethoxybenzyl)-2-{4-[(methylamino)methyl]phenyl}-3,4-dihydro-5H-1,4,8b-triazaacenaphthylen-5-one (1187318-35-9) + trifluoroacetic acid (76-05-1) → N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate (1187317-72-1)

Guidance literature:

With chlorotriisopropylsilane; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

methyl 2-(4-cyanophenyl)imidazo[1,2-a]pyridine-5-carboxylate (1187318-23-5) → N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate (1187317-72-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trichlorophosphate / 20 °C / Reflux

2.1: titanium(IV) isopropylate / methanol / 2 h / 20 °C

3.1: methanol; sodium cyanoborohydride / 24 h

3.2: Saturated solution

4.1: formic acid; water / platinum(IV) oxide / tetrahydrofuran / 4 h / 60 °C

4.2: Saturated solution

5.1: titanium(IV) isopropylate / 1,2-dichloro-ethane / 12 h

5.2: 12 h

5.3: Saturated solution

6.1: chlorotriisopropylsilane; water / 0.5 h / 120 °C / Microwave irradiation

With titanium(IV) isopropylate; methanol; formic acid; chlorotriisopropylsilane; water; sodium cyanoborohydride; trichlorophosphate; titanium(IV) isopropylate; platinum(IV) oxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

Reference yield:

6-aminopicolinic acid (23628-31-1) → N-methyl-[4-(5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl)phenyl]methanamine trifluoroacetate (1187317-72-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sulfuric acid / 20 h / Reflux

1.2: Saturated solution

2.1: sodium hydrogencarbonate / isopropyl alcohol / 36 h / 20 °C / Reflux

3.1: trichlorophosphate / 20 °C / Reflux

4.1: titanium(IV) isopropylate / methanol / 2 h / 20 °C

5.1: methanol; sodium cyanoborohydride / 24 h

5.2: Saturated solution

6.1: formic acid; water / platinum(IV) oxide / tetrahydrofuran / 4 h / 60 °C

6.2: Saturated solution

7.1: titanium(IV) isopropylate / 1,2-dichloro-ethane / 12 h

7.2: 12 h

7.3: Saturated solution

8.1: chlorotriisopropylsilane; water / 0.5 h / 120 °C / Microwave irradiation

With titanium(IV) isopropylate; methanol; formic acid; chlorotriisopropylsilane; sulfuric acid; water; sodium cyanoborohydride; sodium hydrogencarbonate; trichlorophosphate; titanium(IV) isopropylate; platinum(IV) oxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; isopropyl alcohol;

upstream raw materials:

4-(2,4-dimethoxybenzyl)-2-{4-[(methylamino)methyl]phenyl}-3,4-dihydro-5H-1,4,8b-triazaacenaphthylen-5-one

trifluoroacetic acid

6-aminopicolinic acid

methyl 6-aminopyridine-2-carboxylate

Refernces