Technology Process of 4-(2,4-dimethoxybenzyl)-2-{4-[(methylamino)methyl]phenyl}-3,4-dihydro-5H-1,4,8b-triazaacenaphthylen-5-one
There total 7 articles about 4-(2,4-dimethoxybenzyl)-2-{4-[(methylamino)methyl]phenyl}-3,4-dihydro-5H-1,4,8b-triazaacenaphthylen-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-2-yl]benzaldehyde; methylamine hydrochloride;
titanium(IV) isopropylate;
In
1,2-dichloro-ethane;
for 12h;
With
sodium cyanoborohydride;
In
1,2-dichloro-ethane;
for 12h;
With
water; sodium hydrogencarbonate;
In
1,2-dichloro-ethane;
Saturated solution;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 20 h / Reflux
1.2: Saturated solution
2.1: sodium hydrogencarbonate / isopropyl alcohol / 36 h / 20 °C / Reflux
3.1: trichlorophosphate / 20 °C / Reflux
4.1: titanium(IV) isopropylate / methanol / 2 h / 20 °C
5.1: methanol; sodium cyanoborohydride / 24 h
5.2: Saturated solution
6.1: formic acid; water / platinum(IV) oxide / tetrahydrofuran / 4 h / 60 °C
6.2: Saturated solution
7.1: titanium(IV) isopropylate / 1,2-dichloro-ethane / 12 h
7.2: 12 h
7.3: Saturated solution
With
titanium(IV) isopropylate; methanol; formic acid; sulfuric acid; water; sodium cyanoborohydride; sodium hydrogencarbonate; trichlorophosphate;
titanium(IV) isopropylate; platinum(IV) oxide;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 20 °C / Reflux
2.1: titanium(IV) isopropylate / methanol / 2 h / 20 °C
3.1: methanol; sodium cyanoborohydride / 24 h
3.2: Saturated solution
4.1: formic acid; water / platinum(IV) oxide / tetrahydrofuran / 4 h / 60 °C
4.2: Saturated solution
5.1: titanium(IV) isopropylate / 1,2-dichloro-ethane / 12 h
5.2: 12 h
5.3: Saturated solution
With
titanium(IV) isopropylate; methanol; formic acid; water; sodium cyanoborohydride; trichlorophosphate;
titanium(IV) isopropylate; platinum(IV) oxide;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane;