2-cyclopropyl-2-phenylpropiophenone

Base Information

• Chemical Name: 2-cyclopropyl-2-phenylpropiophenone
• CAS No.: 123078-57-9
• Molecular Formula: C₁₈H₁₈O
• Molecular Weight: 250.34
• Mol file: 123078-57-9.mol

Synonyms:2-cyclopropyl-2-phenylpropiophenone

Chemical Property of 2-cyclopropyl-2-phenylpropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclopropyl-2-phenylpropiophenone

There total 9 articles about 2-cyclopropyl-2-phenylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Cyclopropyl-1,2-diphenyl-propan-1-ol → 2-cyclopropyl-2-phenylpropiophenone (123078-57-9)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo00282a020

Reference yield:

2-cyclopropyl-2-phenylacetaldehyde (16282-50-1) → 2-cyclopropyl-2-phenylpropiophenone (123078-57-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 50 percent / silver nitrate, sodium hydroxide / ethanol; H₂O / 24 h / Ambient temperature

2: oxalyl chloride / benzene / 3 h / Ambient temperature

3: pyridine / 3 h / 20 °C

4: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C

5: 99 percent / diisobutylaluminum hydride (Dibal-H) / CH₂Cl₂; hexane / 1 h / -10 °C

6: 89 percent / chromium trioxide, pyridine / CH₂Cl₂ / 1 h / 0 °C

7: 2.) water / 1.) ether, -78 deg C, 30 min, 2.) from -78 deg C to RT

8: 81 percent / chromium trioxide, pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; oxalyl dichloride; water; diisobutylaluminium hydride; silver nitrate; lithium diisopropyl amide; In ethanol; hexane; dichloromethane; water; benzene;

DOI:10.1021/jo00282a020

Reference yield:

methyl 2-cyclopropyl-2-phenylacetate (123078-50-2) → 2-cyclopropyl-2-phenylpropiophenone (123078-57-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C

2: 99 percent / diisobutylaluminum hydride (Dibal-H) / CH₂Cl₂; hexane / 1 h / -10 °C

3: 89 percent / chromium trioxide, pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 2.) water / 1.) ether, -78 deg C, 30 min, 2.) from -78 deg C to RT

5: 81 percent / chromium trioxide, pyridine / CH₂Cl₂ / 3 h / 0 °C

With pyridine; chromium(VI) oxide; water; diisobutylaluminium hydride; lithium diisopropyl amide; In hexane; dichloromethane;

DOI:10.1021/jo00282a020

upstream raw materials:

2-cyclopropyl-2-phenylacetaldehyde

methyl 2-cyclopropyl-2-phenylacetate

2-cyclopropyl(phenyl)ethanoic acid

Cyclopropyl-phenyl-acetyl chloride

Downstream raw materials:

2-cyclopropyl-1,1,2-triphenylpropanol

4-methyl-1,2-dihydronaphthalene

(E)-pent-2-en-2-ylbenzene

α-cyclopropyl ethyl benzene

Refernces