Quinolin-2-ylmethanamine

Base Information

• Chemical Name: Quinolin-2-ylmethanamine
• CAS No.: 5760-20-3
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Hs Code.: 2933499090
• European Community (EC) Number: 815-421-2
• DSSTox Substance ID: DTXSID70206234
• Nikkaji Number: J81.089D
• ChEMBL ID: CHEMBL4586378
• Mol file: 5760-20-3.mol

Synonyms:2-aminomethylquinoline;2-aminomethylquinoline, dihydrochloride

Chemical Property of Quinolin-2-ylmethanamine

Chemical Property:

• Vapor Pressure: 0.00185mmHg at 25°C
• Refractive Index: 1.662
• Boiling Point: 292.3 °C at 760 mmHg
• PKA: 8.70±0.30(Predicted)
• Flash Point: 155.6 °C
• PSA: 38.91000
• Density: 1.156 g/cm³
• LogP: 2.39380
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

98%,99%, ^*data from raw suppliers

Quinolin-2-ylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)CN

Technology Process of Quinolin-2-ylmethanamine

There total 24 articles about Quinolin-2-ylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(quinolin-2-ylmethyl)isoindoline-1,3-dione (67868-38-6) → 2-aminomethylquinoline (5760-20-3)

Guidance literature:

With hydrazine hydrate; for 12h; Reflux;

Reference yield: 85.0%

1-((quinoline-2-yl)methyl)pyrrolidine-2,5-dione → 2-aminomethylquinoline (5760-20-3)

Guidance literature:

With hydrazine hydrate; for 12h; Reflux;

Reference yield: 82.0%

quinolin-2-ylmethanamine bischlorohydrate (18004-62-1) → 2-aminomethylquinoline (5760-20-3)

Guidance literature:

With sodium hydroxide; In water; pH=10;

DOI:10.1016/j.tet.2013.07.090

upstream raw materials:

quinoline-2-carbonitrile

(E)-2-quinolinecarbaldehyde oxime

Quinoline N-oxide

quinoline-2-carboxylic acid

Refernces

• 1、 -. "MANUFACTURING METHOD OF OPTICAL ACTIVE SECONDARY ALCOHOL". Paragraph 0094; 0096; 0098. . Retrieved 2019/03/20.
• 2、 Baucom, Kyle D.,Guram, Anil S.,Borths, Christopher J.. "Effective conversion of heteroaromatic ketones into primary amines via hydrogenation of intermediate ketoximes". supporting information. p. 201 - 204. Retrieved 2015/03/03.