Quinolin-2-ylmethanamine dihydrochloride

Base Information

• Chemical Name: Quinolin-2-ylmethanamine dihydrochloride
• CAS No.: 18004-62-1
• Molecular Formula: C10H12Cl2N2
• Molecular Weight: 231.125
• Hs Code.: 2933499090
• European Community (EC) Number: 825-768-1
• Mol file: 18004-62-1.mol

Synonyms:18004-62-1;quinolin-2-ylmethanamine dihydrochloride;C-quinolin-2-yl-methylamine dihydrochloride;2-(aminomethyl)quinoline dihydrochloride;2-AMINOMETHYLQUINOLINE 2HCL;Quinolin-2-ylmethanamine;dihydrochloride;2-Quinolinemethanamine, hydrochloride (1:2);MFCD05053645;(quinolin-2-yl)methanamine dihydrochloride;1-(QUINOLIN-2-YL)METHANAMINE DIHYDROCHLORIDE;SCHEMBL5211470;XPAZBFLKFMBGMF-UHFFFAOYSA-N;2-Aminomethylquinoline dihydrochloride;2-Quinolinemethanamine dihydrochloride;2-aminomethyl-quinoline dihydrochloride;2-quinolinylmethanamine dihydrochloride;AKOS024262216;quinolin-2-ylmethanaminedihydrochloride;SB34410;AS-30181;SY240439;DB-409911;CS-0060584;EN300-1166953;(QUINOLIN-2-YLMETHYL)AMINE DIHYDROCHLORIDE;2-quinolinylmethylamine dihydrochloride, AldrichCPR;A831518;A934174;Z2106596235

Chemical Property of Quinolin-2-ylmethanamine dihydrochloride

Chemical Property:

• Boiling Point: 355.6 °C at 760 mmHg
• Flash Point: 168.8 °C
• PSA: 38.91000
• LogP: 3.99780
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 230.0377538
• Heavy Atom Count: 14
• Complexity: 147

Purity/Quality:

99% ^*data from raw suppliers

C-Quinolin-2-yl-methylaminedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)CN.Cl.Cl

Technology Process of Quinolin-2-ylmethanamine dihydrochloride

There total 6 articles about Quinolin-2-ylmethanamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N-di-Boc-quinolin-2-ylmethanamine (1393887-11-0) → quinolin-2-ylmethanamine bischlorohydrate (18004-62-1)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 - 90 ℃;

DOI:10.1016/j.tet.2013.07.090

Reference yield: 68.0%

2-Phenyl-4-(2-quinolyl)-2-oxazolin-5-one (76278-23-4) → quinolin-2-ylmethanamine bischlorohydrate (18004-62-1)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

Reference yield: 8.5%

quinoline 2-carbaldehyde (5470-96-2) → quinolin-2-ylmethanamine bischlorohydrate (18004-62-1)

Guidance literature:

quinoline 2-carbaldehyde; With pyridoxal 5'-phosphate; ω-transaminase from Bacillus megaterium; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

upstream raw materials:

2-Phenyl-4-(2-quinolyl)-2-oxazolin-5-one

N,N-di-Boc-quinolin-2-ylmethanamine

quinoline-2-carboxylic acid methyl ester

quinolin-2-ylmethanol

Downstream raw materials:

2-aminomethylquinoline

N-(quinolin-2-ylmethyl)benzamide

N-((1,2,3,4-tetrahydroquinolin-2-yl)methyl)benzamide

2-[1-(3,4-Dimethoxy-benzyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-2-phenyl-N-quinolin-2-ylmethyl-acetamide

Refernces

• 1、 Maj, Anna M.,Suisse, Isabelle,Hardouin, Christophe,Agbossou-Niedercorn, Francine. "Synthesis of new chiral 2-functionalized-1,2,3,4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines". . p. 9322 - 9328. Retrieved 2013/10/01.