METHYL (R)-3-PHENYLBUTYRATE

Base Information

• Chemical Name: METHYL (R)-3-PHENYLBUTYRATE
• CAS No.: 1472-07-7
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Mol file: 1472-07-7.mol

Synonyms:methyl (R)-3-phenylbutanoate

Chemical Property of METHYL (R)-3-PHENYLBUTYRATE

Chemical Property:

• Vapor Pressure: 0.0537mmHg at 25°C
• Refractive Index: n20/D 1.497
• Density: 1.020?g/mL?at 20?°C(lit.)

Purity/Quality:

98%Min ^*data from raw suppliers

METHYL-(R)-3-PHENYLBUTYRATE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

Useful:

Technology Process of METHYL (R)-3-PHENYLBUTYRATE

There total 23 articles about METHYL (R)-3-PHENYLBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + (4R)-4-phenyl-3-<(3R)-3-phenylbutyryl>oxazolidin-2-one (160538-63-6) → methyl (R)-3-phenylbutanoate (1472-07-7)

Guidance literature:

With ytterbium(III) triflate; at 60 ℃; for 1h;

DOI:10.1021/acs.joc.8b02451

Reference yield: 98.0%

methyl trans-3-methylcinnamate (3461-50-5) → methyl (R)-3-phenylbutanoate (1472-07-7)

Guidance literature:

With methanol; sodium tetrahydroborate; CoCl₂((R,R)-NaphdiPIM-dioxo-iPr); In dichloromethane; at 0 - 25 ℃; for 1h; enantioselective reaction; Schlenk technique;

DOI:10.1002/cctc.201500260

Reference yield: 91.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (R)-3-phenylbutyric acid (772-14-5) → methyl (R)-3-phenylbutanoate (1472-07-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/ja952835t

upstream raw materials:

diazomethane

(2S)-2-phenylpropionyl chloride

(-)-(R)-Methyl 3-(mesyloxy)butanoate

benzene

Downstream raw materials:

(R)-3-phenylbutanol

3-phenylbutanal

(2R)-sec-butylbenzene

(R)-3-phenylbutyric acid

Refernces

• 1、 Chen, Hang,Chen, Dong-Huang,Huang, Pei-Qiang. "Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions". . p. 370 - 376. Retrieved 2020/03/03.
• 2、 Huang, Pei-Qiang,Geng, Hui. "Ni-Catalyzed chemoselective alcoholysis of: N -acyloxazolidinones". supporting information. p. 593 - 599. Retrieved 2018/02/14.