2-BROMO-10-THIAXANTHENONE

Base Information

• Chemical Name: 2-BROMO-10-THIAXANTHENONE
• CAS No.: 20077-10-5
• Molecular Formula: C13H7 Br O S
• Molecular Weight: 291.168
• Hs Code.: 2932999099
• Mol file: 20077-10-5.mol

Synonyms:Thioxanthen-9-one,2-bromo- (6CI,8CI); 2-Bromothioxanthen-9-one; 2-Bromothioxanthone; NSC 252143

Chemical Property of 2-BROMO-10-THIAXANTHENONE

Chemical Property:

• Melting Point: 233-234 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 422.0±44.0 °C(Predicted)
• PSA: 45.31000
• Density: 1.633±0.06 g/cm3(Predicted)
• LogP: 4.17720

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-3H-thioxanthen-4(9H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-10-THIAXANTHENONE

There total 9 articles about 2-BROMO-10-THIAXANTHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(4-bromo-phenylsulfanyl)benzoic acid (13420-76-3) → 2-bromothioxanthone (20077-10-5)

Guidance literature:

With sulfuric acid; at 100 ℃; for 1h;

DOI:10.1002/anie.202109519

Reference yield: 80.3%

bromobenzene (108-86-1,52753-63-6) + Thiosalicylic acid (147-93-3) → 2-bromothioxanthone (20077-10-5)

Guidance literature:

bromobenzene; With sulfuric acid; at 20 ℃; for 0.5h;

Thiosalicylic acid; at 20 - 100 ℃;

Reference yield: 69.0%

thio-xanthene-9-one (492-22-8) → 2-bromothioxanthone (20077-10-5)

Guidance literature:

With bromine; acetic acid; In chloroform; at 80 ℃; for 72h; Inert atmosphere;

upstream raw materials:

2-amino-9H-thioxanthen-9-one

bromobenzene

Thiosalicylic acid

thio-xanthene-9-one

Downstream raw materials:

2-bromo-9H-thioxanthene-9-one-10,10-dioxide

2-[5-hydroxy-4-(2-nitrophenyl)pent-1-yn-1-yl]-9H-thioxanthen-9-one

2-[5-{[tert-butyl(dimethyl)silyl]oxy}-4-(2-nitrophenyl)pentyl]-9H-thioxanthen-9-one

2-[3-(2-hydroxy-1-methylethyl)-4-nitrophenyl]-9H-thioxanthene-9-one

Refernces

• 1、 Pecho, Franziska,Zou, You-Quan,Gramüller, Johannes,Mori, Tadashi,Huber, Stefan M.,Bauer, Andreas,Gschwind, Ruth M.,Bach, Thorsten. "A Thioxanthone Sensitizer with a Chiral Phosphoric Acid Binding Site: Properties and Applications in Visible Light-Mediated Cycloadditions". . p. 5190 - 5194. Retrieved 2020.
• 2、 Shi, Zeyu,Chen, Si,Xiao, Qiong,Yin, Dali. "Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Their Use in Synthesis". . p. 3334 - 3343. Retrieved 2021/02/05.