protoporphyrinogen IX

Base Information

• Chemical Name: protoporphyrinogen IX
• CAS No.: 7412-77-3
• Molecular Formula: C34H40 N4 O4
• Molecular Weight: 568.716
• DSSTox Substance ID: DTXSID90225068
• Nikkaji Number: J1.944.003F
• Wikipedia: Protoporphyrinogen_IX
• Wikidata: Q925685
• Metabolomics Workbench ID: 37600
• Mol file: 7412-77-3.mol

Synonyms:protoporphyrinogen;protoporphyrinogen IX

Chemical Property of protoporphyrinogen IX

Chemical Property:

• XLogP3: 5.7
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 568.30495577
• Heavy Atom Count: 42
• Complexity: 1010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2CC3=C(C(=C(N3)CC4=C(C(=C(N4)CC5=C(C(=C(N5)CC(=C1CCC(=O)O)N2)CCC(=O)O)C)C=C)C)C=C)C

Technology Process of protoporphyrinogen IX

There total 2 articles about protoporphyrinogen IX which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

coproporphyrinogen III (2624-63-7) → harderoporphyrinogen IX (7412-77-3)

Guidance literature:

With ethylenediaminetetraacetic acid; coprophyrinogen III oxidase; In water; at 37 ℃; for 1h; pH=7.15; Enzyme kinetics;

DOI:10.1021/ac702130n

Reference yield:

coproporphyrinogen III (2624-63-7) → harderoporphyrinogen-III (42607-18-1) + harderoporphyrinogen IX (7412-77-3)

Guidance literature:

With 1H-imidazole; oxygen; coproporphyrinogen oxidase; In water; at 37 ℃; pH=7.0; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/j.bmc.2005.06.051

Reference yield:

harderoporphyrinogen IX (7412-77-3) → protoporphyrin IX (553-12-8)

Guidance literature:

With 1H-imidazole; Bacillus subtilis protoporphyrinogen oxidase; flavin adenine dinucleotide; In phosphate buffer; dimethyl sulfoxide; at 25 ℃; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/S0045-2068(03)00093-2

upstream raw materials:

coproporphyrinogen III

Downstream raw materials:

protoporphyrin IX

protoporphyrin IX

Refernces

• 1、 Donegan, Rebecca K.,Moore, Courtney M.,Hanna, David A.,Reddi, Amit R.. "Handling heme: The mechanisms underlying the movement of heme within and between cells". . p. 88 - 100. Retrieved 2018/08/21.
• 2、 Cooper, Christopher L.,Stob, Christian M.,Jones, Marjorie A.,Lash, Timothy D.. "Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: Further evidence for the existence of an abnormal pathway for heme biosynthesis". . p. 6244 - 6251. Retrieved 2007/10/03.