Harderoporphyrinogen

Base Information

• Chemical Name: Harderoporphyrinogen
• CAS No.: 42607-18-1
• Molecular Formula: C35H42N4O6
• Molecular Weight: 614.742
• Mol file: 42607-18-1.mol

Synonyms:

Chemical Property of Harderoporphyrinogen

Chemical Property:

• Boiling Point: 840.3°Cat760mmHg
• Flash Point: 462°C
• PSA: 164.77000
• Density: 1.36g/cm³
• LogP: 3.86060

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Harderoporphyrinogen

There total 3 articles about Harderoporphyrinogen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{5-Formyl-2-[5-formyl-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester (4792-10-3) → harderoporphyrinogen-III (42607-18-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 20 °C / Darkness

1.2: 10 h

1.3: 14 h / Darkness

2.1: zinc diacetate / methanol; dichloromethane / 2 h / Darkness

3.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 72 h / Darkness

3.2: 14 h / Darkness

4.1: hydrogenchloride; water / 6 h / 20 °C

5.1: sodium amalgam; potassium hydroxide / 0.08 h / 80 °C / Darkness

With hydrogenchloride; sodium amalgam; potassium tert-butylate; zinc diacetate; water; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;

DOI:10.1515/BC.2010.006

Reference yield:

coproporphyrinogen III (2624-63-7) → harderoporphyrinogen-III (42607-18-1)

Guidance literature:

With ethylenediaminetetraacetic acid; coproporphyrinogen III oxidase; In water; at 37 ℃; pH=7.15;

DOI:10.1021/ac702130n

Reference yield:

coproporphyrinogen III (2624-63-7) → harderoporphyrinogen-III (42607-18-1) + harderoporphyrinogen IX (7412-77-3)

Guidance literature:

With 1H-imidazole; oxygen; coproporphyrinogen oxidase; In water; at 37 ℃; pH=7.0; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.1016/j.bmc.2005.06.051

upstream raw materials:

coproporphyrinogen III

3-{5-Formyl-2-[5-formyl-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester

Downstream raw materials:

3-vinyl-2,7,12,18-tetramethylporphyrin-8,13,17-tripropionic acid

protoporphyrin IX

Refernces

• 1、 Ji, Xinjian,Mo, Tianlu,Liu, Wan-Qiu,Ding, Wei,Deng, Zixin,Zhang, Qi. "Revisiting the Mechanism of the Anaerobic Coproporphyrinogen III Oxidase HemN". supporting information. p. 6235 - 6238. Retrieved 2019/04/04.
• 2、 Wang, Yuesong,Gatti, Paula,Sadilek, Martin,Scott, C. Ronald,Turecek, Frantisek,Gelb, Michael H.. "Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase". . p. 2599 - 2605. Retrieved 2008/09/20.