Sodium picosulfate

Base Information

• Chemical Name: Sodium picosulfate
• CAS No.: 10040-45-6
• Molecular Formula: C18H13NNa2O8S2
• Molecular Weight: 481.415
• Hs Code.: 2933399090
• Mol file: 10040-45-6.mol

Synonyms:Phenol,4,4'-(2-pyridinylmethylene)bis-, bis(hydrogen sulfate) (ester), disodium salt(9CI);Phenol, 4,4'-(2-pyridylmethylene)di-, bis(hydrogen sulfate) (ester)disodium salt (8CI);4,4'-(2-Pyridylmethylene)diphenol bis(hydrogen sulfate)disodium salt;DA 1773;Disodium bis[4-[(hydroxysulfonyl)oxy]phenyl](2-pyridyl)methane;Evacuol;Guttalax;Guttalax-Fher;LA 391;Laxoberal;Laxoberon;Neopax;Pico-Salax;Picolax;Picosulfate sodium;Picosulfol;Rapilax;Sodiumpicosulfate;

Chemical Property of Sodium picosulfate

Chemical Property:

• Appearance/Colour: gray powder complex
• Melting Point: 272 - 275oC
• PSA: 162.51000
• LogP: 4.10140
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: Freely soluble in water, slightly soluble in ethanol 96 per cent.

Purity/Quality:

99.8% ^*data from raw suppliers

PicosulfateSodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium picosulfate acts as a stimulant laxative by increasing the frequency and the force of peristalsis and promoting electrolyte and water retention in the colon. Sodium picosulfate is most often used as laxatives. Sodium picosulfate is a stimulant laxative related to bis-acedyl; used for the treatment of constipation and for evaluation of the colon by stimulation bowel movements following hydrolysis by colon bacteria.
• Therapeutic Function: Laxative

Technology Process of Sodium picosulfate

There total 4 articles about Sodium picosulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

4,4'-(2-pyridylmethylene)diphenol (603-41-8) → Guttalax (10040-45-6)

Guidance literature:

4,4'-(2-pyridylmethylene)diphenol; With pyridine; chlorosulfonic acid; at 0 - 20 ℃; for 5h;

With sodium hydroxide; Concentration; Cooling with ice;

Reference yield:

→ Guttalax (10040-45-6)

Guidance literature:

Dinatrium-p,p'-picolyliden-(2)-bis-(o,o'-dibrom-phenylsulfat), Ni-Al/NaOH (-Red.) (Ausb.62percent);

DOI:10.1002/hlca.19680510521

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → Guttalax (10040-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 - 65 °C / Inert atmosphere; Large scale

1.2: 4 h / 10 - 20 °C / Inert atmosphere; Large scale

2.1: hydrogen iodide; acetic acid / 6 h / 100 °C / Large scale

3.1: pyridine; chlorosulfonic acid / 12 h / 10 - 25 °C / Inert atmosphere; Large scale

3.2: 0 °C / pH 11 / Inert atmosphere; Large scale

With pyridine; chlorosulfonic acid; hydrogen iodide; magnesium; acetic acid; In tetrahydrofuran;

upstream raw materials:

4,4'-(2-pyridylmethylene)diphenol

1-bromo-4-methoxy-benzene

ethyl-2-picolinate

Downstream raw materials:

4-((4-hydroxyphenyl)(pyridin-2-yl)methyl)phenyl hydrogen sulfate

4,4'-(2-pyridylmethylene)diphenol

Refernces

• 1、 -. "Method for preparing high-purity sodium picosulfate intermediate and sodium picosulfate". Paragraph 0058-0059. . Retrieved 2021/05/29.
• 2、 -. "A process for preparing sodium method". Paragraph 0054-0055; 0060. . Retrieved 2017/08/31.