Dihydroxydiphenyl-pyridyl methane

Base Information

• Chemical Name: Dihydroxydiphenyl-pyridyl methane
• CAS No.: 603-41-8
• Molecular Formula: C18H15NO2
• Molecular Weight: 277.323
• Hs Code.: 2933399090
• European Community (EC) Number: 210-039-7
• UNII: R09078E41Y
• DSSTox Substance ID: DTXSID20209053
• Nikkaji Number: J86.639C
• Wikidata: Q27287600
• RXCUI: 1872905
• Metabolomics Workbench ID: 154881
• ChEMBL ID: CHEMBL3544537
• Mol file: 603-41-8.mol

Synonyms:bis(p-hydroxyphenyl)pyridyl-2-methane;DDPM;deacetylbisacodyl;desacetyl-bisacodyl;desacetylbisacodyl;dihydroxydiphenyl-pyridyl methane

Chemical Property of Dihydroxydiphenyl-pyridyl methane

Chemical Property:

• Melting Point: >200°C (dec.)
• Boiling Point: 462.1 °C at 760 mmHg
• PKA: 9.71±0.10(Predicted)
• Flash Point: 233.3 °C
• PSA: 53.35000
• Density: 1.244 g/cm³
• LogP: 3.67300
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 277.110278721
• Heavy Atom Count: 21
• Complexity: 284

Purity/Quality:

99.9% ^*data from raw suppliers

DeacetylBisacodyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O
• Uses: The active form of Bisacodyl. Cathartic. The active form of Bisacodyl. Cathartic

Technology Process of Dihydroxydiphenyl-pyridyl methane

There total 25 articles about Dihydroxydiphenyl-pyridyl methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

bisacodyl (603-50-9) → 4,4'-(2-pyridylmethylene)diphenol (603-41-8)

Guidance literature:

bisacodyl; With sodium hydroxide; In ethanol; water; at 30 - 40 ℃; for 4h;

With hydrogenchloride; In water; at 20 ℃; for 0.5h; Reagent/catalyst; Temperature;

Reference yield: 95.7%

3,3'-dichloro-4,4'-(pyridin-2-ylmethylene)diphenol → 4,4'-(2-pyridylmethylene)diphenol (603-41-8)

Guidance literature:

With nickel aluminum; sodium hydroxide; at 20 ℃; for 9h; Concentration;

Reference yield: 80.0%

3-(4-methoxyphenyl)-[l,2,3]triazolo[1,5-a]pyridine (78539-92-1) + (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid (159191-56-7) → 4,4'-(2-pyridylmethylene)diphenol (603-41-8)

Guidance literature:

3-(4-methoxyphenyl)-[l,2,3]triazolo[1,5-a]pyridine; (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid; With potassium carbonate; In benzene; at 20 ℃; for 10h; UV-irradiation;

With hydrogen bromide; acetic acid; Reflux;

DOI:10.1039/c9sc02448d

upstream raw materials:

pyridine-2-carbaldehyde

phenol

4,4'-(pyridin-2-ylmethylene)dianiline

di[4'',4'''-di(methoxy)phenyl](2'-pyridyl)methanol

Downstream raw materials:

Guttalax

bisacodyl

Refernces

• 1、 -. "Preparation method of sodium picosulfate". Paragraph 0040-0042; 0045-0047; 0050-0052; 0055-0057; .... . Retrieved 2021/09/15.
• 2、 -. "Colloidal gold detection kit for sodium picosulfate, bisacodyl and deacetylated bisacodyl and application of colloidal gold detection kit". Paragraph 0059-0060. . Retrieved 2021/05/26.