CIS-1,4-CYCLOHEXANEDIAMINE

Base Information

• Chemical Name: CIS-1,4-CYCLOHEXANEDIAMINE
• CAS No.: 15827-56-2
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 29213000
• Mol file: 15827-56-2.mol

Synonyms:cis-1,4-Diaminocyclohexane;

Chemical Property of CIS-1,4-CYCLOHEXANEDIAMINE

Chemical Property:

• Vapor Pressure: 0.342mmHg at 25°C
• Refractive Index: 1.483
• Boiling Point: 199.401 °C at 760 mmHg
• PKA: 10.78±0.70(Predicted)
• Flash Point: 80 °C
• PSA: 52.04000
• Density: 0.939 g/cm³
• LogP: 1.61560
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-Cyclohexane-1,4-diamine ^*data from reagent suppliers

Safty Information:

• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-1,4-CYCLOHEXANEDIAMINE

There total 10 articles about CIS-1,4-CYCLOHEXANEDIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,4-Cyclohexanedione (637-88-7) → cis-1,4-cyclohexanediamine (15827-56-2)

Guidance literature:

With chloro[N-[4-(dimethylamino)phenyl]-2-pyridinecarboxamidato](pentamethylcyclopentadienyl)iridium; ammonium formate; acetic acid; In water; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.9b01565

Reference yield: 35.6%

1,4-Cyclohexanediol (556-48-9) → trans-1,4-cyclohexyldiamine (2615-25-0) + cis-1,4-cyclohexanediamine (15827-56-2)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; 4,5-bis((diisopropylphosphanyl)methyl)acridine; ammonia; In tert-Amyl alcohol; at 170 ℃; for 21h; Temperature; Inert atmosphere; Schlenk technique; Autoclave;

DOI:10.1002/cctc.201300407

Reference yield:

1,4-phenylenediamine (106-50-3) → trans-1,4-cyclohexyldiamine (2615-25-0) + cis-1,4-cyclohexanediamine (15827-56-2) + p-hydroxycyclohexylamine (6850-65-3) + cyclohexylamine (108-91-8,157973-60-9) + cyclohexanol (108-93-0)

Guidance literature:

With Ru/Al₂O₃; water; hydrogen; In isopropyl alcohol; at 90 ℃; for 0.75h; under 30003 Torr; Autoclave; Inert atmosphere;

DOI:10.1134/S1070427214030239

upstream raw materials:

4-nitro-aniline

cis-1.4-bis-methoxycarbonylamino-cyclohexane

1,4-Cyclohexanediol

1,4-phenylenediamine

Downstream raw materials:

cis-cyclohexane-1,4-diacetamide

Refernces

• 1、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.
• 2、 -. "PRODUCTION METHOD OF TRANS-DIAMINOCYCLOHEXANE". Paragraph 0062; 0073. . Retrieved 2016/12/16.