PYRVINIUM PAMOATE

Base Information

• Chemical Name: PYRVINIUM PAMOATE
• CAS No.: 3546-41-6
• Molecular Formula: C75H70N6O6
• Molecular Weight: 1151.51
• Hs Code.: 2933492250
• Mol file: 3546-41-6.mol

Synonyms:6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-quinoliniu;alnoxin;altolat;methyl-,saltwith4,4’-methylenebis(3-hydroxy-2-naphthoicacid)(2:1);molevac;neo-oxypate;pamovin;pirviniumpamoate

Chemical Property of PYRVINIUM PAMOATE

Chemical Property:

• Melting Point: 210-215° (softens at 190°)
• Refractive Index: 1.6400 (estimate)
• Boiling Point: 829.27°C (rough estimate)
• PSA: 144.82000
• Density: 1.0104 (rough estimate)
• LogP: 12.33840
• Storage Temp.: room temp
• Solubility.: DMSO: >10mg/mL

Purity/Quality:

99% ^*data from raw suppliers

Pyrvinium pamoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-40
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Indications: Infections caused by Enterobius vermicularis. Pyrvinium is largely replaced today by more effective and safer drugs such as albendazole and mebendazole.
• Uses: anthelmintic Pyrvinium Pamoate is a potent noncompetitive inhibitor of the androgen receptor, with the application towards prostate cancer treatment. Antihelmintic.

Technology Process of PYRVINIUM PAMOATE

There total 5 articles about PYRVINIUM PAMOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl]-1-methyl-6-(dimethylamino)quinolinium methyl sulphate salt (61791-77-3) + embonic acid disodium salt (6640-22-8,7681-47-2,15537-67-4) → pyrvinium pamoate (3546-41-6)

Guidance literature:

With ammonia; In water; Reflux;

Reference yield:

embonic acid disodium salt (6640-22-8,7681-47-2,15537-67-4) + (E)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium iodide (35648-29-4) → pyrvinium pamoate (3546-41-6)

Guidance literature:

In methanol; water;

DOI:10.1016/j.bmcl.2020.127037

Reference yield:

4-amino-N,N-dimethylaniline (99-98-9) → pyrvinium pamoate (3546-41-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / toluene / Reflux

2: Sealed tube

3: piperidine / methanol / Reflux

4: methanol; water

With piperidine; hydrogenchloride; In methanol; water; toluene;

DOI:10.1016/j.bmcl.2020.127037

upstream raw materials:

(E)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl]-1-methyl-6-(dimethylamino)quinolinium methyl sulphate salt

embonic acid disodium salt

4-amino-N,N-dimethylaniline

(E)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium iodide

Refernces

• 1、 -. "Pharmaceutical composition and process of treatment". . . Retrieved 2008/06/13.