chalcone

Base Information

• Chemical Name: chalcone
• CAS No.: 252353-08-5
• Molecular Formula: C₃₈H₄₅NO₇
• Molecular Weight: 627.778
• Mol file: 252353-08-5.mol

Synonyms:chalcone

Chemical Property of chalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chalcone

There total 5 articles about chalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-(piperidin-1-yl)ethoxy)benzaldehyde (26815-04-3) + 1-(2-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone (130064-21-0) → chalcone (252353-08-5)

Guidance literature:

With piperidine; In toluene; Heating / reflux;

Reference yield:

2,4,4'-trihydroxy deoxybenzoin (17720-60-4,423150-69-0) → chalcone (252353-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / ethyl acetate / 16 h / 25 °C / Inert atmosphere

2: piperidine / toluene / Inert atmosphere; Dean-Stark; Reflux; Large scale

With piperidine; toluene-4-sulfonic acid; In ethyl acetate; toluene;

Reference yield:

recorcinol (108-46-3) → chalcone (252353-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / toluene / 1 h / 100 °C

2: toluene-4-sulfonic acid / ethyl acetate / 16 h / 25 °C / Inert atmosphere

3: piperidine / toluene / Inert atmosphere; Dean-Stark; Reflux; Large scale

With piperidine; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In ethyl acetate; toluene;

upstream raw materials:

4-(2-(piperidin-1-yl)ethoxy)benzaldehyde

1-(2-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

2,4,4'-trihydroxy deoxybenzoin

recorcinol

Downstream raw materials:

4-hydroxy-4-methyl-2-(4'-[2''-piperidino]ethoxy)phenyl-3-(4'''-tetrahydropyranyloxy)phenyl-7-tetrahydropyranyloxychromane

Refernces

• 1、 -. "TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM". Paragraph 0228; 0229; 0232. . Retrieved 2015/09/28.