Technology Process of Frustulosinol
There total 13 articles about Frustulosinol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at -78 ℃;
for 0.1h;
DOI:10.1021/jo00134a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 35 percent / 1.) n-butyllithium, 2.) ethylene iodochloride / tetrahydrofuran / 1.) room temperature, 35 min, 2.) 0 deg C, 0.5 h
2: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
3: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
4: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
5: 68 percent / NaBH4 / methanol / 0.1 h / -78 °C
With
sodium tetrahydroborate; n-butyllithium; boron tribromide; ethylene iodochloride; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00134a009
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-butyllithium, 2.) ethylene iodochloride / 1.) pentane, 0 deg C, 6 h, 2.) ether, from 0 deg C to 15 deg C, 2 h
2: 85 percent / Hg(OAc)2 / methanol / 0.5 h
3: 83 percent / pyridinium chlorochromate / acetone; CH2Cl2
4: 86 percent / BBr3 / CH2Cl2 / 4 h / Ambient temperature
5: 5 mg / dimethylformamide / 3 h / 70 - 90 °C
6: 68 percent / NaBH4 / methanol / 0.1 h / -78 °C
With
sodium tetrahydroborate; n-butyllithium; mercury(II) diacetate; boron tribromide; ethylene iodochloride; pyridinium chlorochromate;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00134a009
