4-Morpholinepropanoic acid, methyl ester

Base Information

• Chemical Name: 4-Morpholinepropanoic acid, methyl ester
• CAS No.: 33611-43-7
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Hs Code.: 2934999090
• European Community (EC) Number: 626-796-5
• NSC Number: 408953
• UNII: 4GK6TKD4AE
• DSSTox Substance ID: DTXSID4067775
• Nikkaji Number: J69.005H
• Wikidata: Q81994422
• ChEMBL ID: CHEMBL1195667
• Mol file: 33611-43-7.mol

Synonyms:33611-43-7;Methyl 3-morpholinopropionate;Methyl 4-morpholinepropionate;4-Morpholinepropanoic acid, methyl ester;Methyl 3-morpholinopropanoate;methyl 3-morpholin-4-ylpropanoate;methyl 3-(morpholin-4-yl)propanoate;Methyl 3-(4-morpholinyl)propanoate;4GK6TKD4AE;methyl-3-morpholinopropionate;MFCD00023391;NSC 408953;NSC-408953;AI3-23312;3-morpholin-4-yl-propionic acid methyl ester;Methyl4-morpholinepropionate;UNII-4GK6TKD4AE;SCHEMBL66238;methyl 3-mor-pholinopropanoate;CHEMBL1195667;DTXSID4067775;Methyl 4-morpholinepropionate, 99%;BBL027890;NSC408953;STK500252;VT1309;AKOS000321203;Methyl 3-(4-morpholinyl)propanoate #;3-Morpholinopropanoic acid methyl ester;AC-23461;CS-11269;SY013056;BB 0240882;CS-0204262;FT-0639117;EN300-16259;4-(2-(METHOXYCARBONYL)ETHYL)MORPHOLINE;A821874;J-019273;Z53116548

Chemical Property of 4-Morpholinepropanoic acid, methyl ester

Chemical Property:

• Vapor Pressure: 0.0213mmHg at 25°C
• Refractive Index: n20/D 1.459(lit.)
• Boiling Point: 250.8 °C at 760 mmHg
• PKA: 5.98±0.10(Predicted)
• Flash Point: 105.5 °C
• PSA: 38.77000
• Density: 1.065 g/cm³
• LogP: -0.18040
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 173.10519334
• Heavy Atom Count: 12
• Complexity: 143

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 3-morpholinopropionate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CCN1CCOCC1
• Uses: Methyl 3-Morpholin-4-ylpropanoate is used in method for preparation steric hindrance adjustable weak base light stabilizers with effective light stability and antioxidation stability protection for polymer material.

Technology Process of 4-Morpholinepropanoic acid, methyl ester

There total 6 articles about 4-Morpholinepropanoic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-morpholinopropionate (33611-43-7)

Guidance literature:

With silica-supported aluminum chloride; at 60 ℃; for 2h; Neat (no solvent);

DOI:10.1080/00397910802499559

Reference yield: 98.0%

→ methyl 3-morpholinopropionate (33611-43-7)

Guidance literature:

Reference yield: 89.0%

morpholine (110-91-8,99108-56-2) + methyl 3-chloropropionate (6001-87-2) → methyl 3-morpholinopropionate (33611-43-7)

Guidance literature:

morpholine; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 0.25h;

methyl 3-chloropropionate; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1080/14786410802090359

upstream raw materials:

morpholine

acrylic acid methyl ester

isopropylamine

methyl 3-chloropropionate

Downstream raw materials:

3-morpholin-4-ylpropionic acid

perfluoro(N-ethylmorpholine)

perfluorodiethyl ether

2,2,3,3,5,5,6,6-Octafluoro-4-trifluoromethyl-morpholine

Refernces

• 1、 Jian Fui, Choong,Lutfor Rahman, Md,Musta, Baba,Sani Sarjadi, Mohd,Sarkar, Shaheen M.,Xin Ting, Tang. "Bio-heterogeneous Cu(0)NC@PHA for n-aryl/alkylation at room temperature". . . Retrieved 2021/06/28.
• 2、 Gopiraman, Mayakrishnan,Saravanamoorthy, Somasundaram,Baskar, Ramaganthan,Ilangovan, Andivelu,Ill-Min, Chung. "Green synthesis of Ag@Au bimetallic regenerated cellulose nanofibers for catalytic applications". . p. 17090 - 17103. Retrieved 2019/11/14.