Hydroxylamine-O-sulfonic acid

Base Information

• Chemical Name: Hydroxylamine-O-sulfonic acid
• CAS No.: 2950-43-8
• Deprecated CAS: 135484-95-6,1085697-83-1
• Molecular Formula: H3NO4S
• Molecular Weight: 113.094
• Hs Code.: 28111980
• European Community (EC) Number: 220-971-6
• DSSTox Substance ID: DTXSID50883542
• Nikkaji Number: J208.587I
• Wikipedia: Hydroxylamine-O-sulfonic_acid
• Wikidata: Q21057234
• Mol file: 2950-43-8.mol

Synonyms:hydroxylamine-O-sulfonic acid

Chemical Property of Hydroxylamine-O-sulfonic acid

Chemical Property:

• Appearance/Colour: white to slightly beige crystalline powder
• Vapor Pressure: 0-53.329Pa at 25-39℃
• Melting Point: 210 °C (dec.)(lit.)
• Refractive Index: 1.534
• Boiling Point: 39 °C(Press: 0.4 Torr)
• PKA: -6.47±0.18(Predicted)
• PSA: 98.00000
• Density: 1.98 g/cm³
• LogP: 0.46060
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: 675g/l (slow decomposition)
• Water Solubility.: soluble
• XLogP3: -3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 112.97827875
• Heavy Atom Count: 6
• Complexity: 104

Purity/Quality:

99% ^*data from raw suppliers

TBX5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C, N
• Hazard Codes: C,N
• Statements: 34-50-43-40-22
• Safety Statements: 26-36/37/39-45-61-28A-27-22

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Hydroxylamines
• Canonical SMILES: NOS(=O)(=O)O
• Uses: Hydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion. Hydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid. HOSA may be used as an aminating reagent in the synthesis of:1-aminotetrazoles and 2-aminotetrazolesN-aminopiperidine (NAPP)1H,1′ H-2,2′-biimidazole-1,1′-diamine

Technology Process of Hydroxylamine-O-sulfonic acid

There total 17 articles about Hydroxylamine-O-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

chlorosulfonic acid (7790-94-5) + hydroxyammonium sulfate → hydroxylamine-O-sulfonic acid (2950-43-8)

Guidance literature:

at 100 ℃;

DOI:10.1002/ejoc.201900485

Reference yield: 71.0%

→ O-ethyl hydroxylamine (624-86-2) + hydroxylamine-O-sulfonic acid (2950-43-8)

Guidance literature:

Reference yield: 69.0%

→ O-2-butenylhydroxylamine (128351-46-2) + hydroxylamine-O-sulfonic acid (2950-43-8)

Guidance literature:

upstream raw materials:

nitromethane

sulfur trioxide

hydroxylamine

sulfuric acid

Downstream raw materials:

p-Chloro-b-methylphenylethylamine

4-bromo-2,5-difluoro-benzonitrile

2-Cyano-4'-methylbiphenyl

4-(1,3-Benzodioxol-5-ylmethoxy)-2-hydroxybenzonitrile

Refernces

• 1、 Liu, Bin,Yuan, Xia,Xu, Bo,Zhang, Han,Li, Ridong,Wang, Xin,Ge, Zemei,Li, Runtao. "Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors". . p. 1 - 15. Retrieved 2019/03/17.
• 2、 -. "Antimicrobial 1,3-disubstituted/imidazolium salts". . . Retrieved 2008/06/13.