N-Methyldodecanamide

Base Information

• Chemical Name: N-Methyldodecanamide
• CAS No.: 27563-67-3
• Molecular Formula: C13H27 N O
• Molecular Weight: 213.363
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID00181964
• Nikkaji Number: J46.006K
• Wikidata: Q63391902
• Mol file: 27563-67-3.mol

Synonyms:N-Methyldodecanamide;27563-67-3;N-Methyllauramide;N-Methyl dodecanamide;Dodecanamide, N-methyl-;N-Lauroylmethylamine;N-Dodecanoylmethylamine;SCHEMBL2905304;DTXSID00181964;CBA56367;MFCD00051780;AKOS009158966;AS-57955;CS-0207165;M2452;D91599;Q63391902

Chemical Property of N-Methyldodecanamide

Chemical Property:

• Vapor Pressure: 0.00177mmHg at 25°C
• Melting Point: 67-68°C
• Boiling Point: 293°Cat760mmHg
• PKA: 16.53±0.46(Predicted)
• Flash Point: 176.3°C
• PSA: 29.10000
• Density: 0.856g/cm³
• LogP: 4.04420
• Solubility.: soluble in Methanol
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 10
• Exact Mass: 213.209264485
• Heavy Atom Count: 15
• Complexity: 146

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyldodecanamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCC(=O)NC

Technology Process of N-Methyldodecanamide

There total 2 articles about N-Methyldodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzyl-N-methyldodecanamide → lauric acid methylamide (27563-67-3) + benzaldehyde (100-52-7)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 20 ℃; for 18h; Product distribution;

DOI:10.1055/s-2007-990795

Reference yield:

methyl n-dodecanoate (111-82-0) → lauric acid methylamide (27563-67-3) + undecyl cyanide (2437-25-4)

Guidance literature:

With ammonia; at 300 ℃; for 0.00122222h; Reagent/catalyst;

DOI:10.1016/j.jcat.2013.05.032

Reference yield: 95.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + lauric acid methylamide (27563-67-3) + carbon monoxide (201230-82-2) → N-acyl sarcosinate (97-78-9)

Guidance literature:

With sulfuric acid; palladium; lithium bromide; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 16h; under 45004.5 Torr; Reagent/catalyst; Temperature; Catalytic behavior; Inert atmosphere; Autoclave;

DOI:10.1021/acs.oprd.7b00326

upstream raw materials:

methyl n-dodecanoate

Downstream raw materials:

N-methyldodecylamine

N-acyl sarcosinate

methyl n-dodecanoate

ethyl laurate

Refernces

• 1、 Kuang, Liping,Zhou, Jing,Chen, Sheng,Ding, Ke. "Room-temperature debenzylation of N-benzylcarboxamides by N-bromosuccinimide". . p. 3129 - 3134. Retrieved 2008/03/28.