Leucomalachite green

Base Information

• Chemical Name: Leucomalachite green
• CAS No.: 129-73-7
• Molecular Formula: C23H26N2
• Molecular Weight: 330.473
• Hs Code.: 29215900
• European Community (EC) Number: 204-961-9
• NSC Number: 36379
• UNII: 8U61G37Z20
• DSSTox Substance ID: DTXSID7031531
• Nikkaji Number: J5.427E
• Wikidata: Q27271024
• ChEMBL ID: CHEMBL1898627
• Mol file: 129-73-7.mol

Synonyms:4,4'-benzylidenebis(N,N-dimethylaniline);leucomalachite green

Chemical Property of Leucomalachite green

Chemical Property:

• Appearance/Colour: white to light brown, light green or light blue
• Melting Point: 100-102 °C
• Boiling Point: 475.4 °C at 760 mmHg
• PKA: 5.62±0.24(Predicted)
• Flash Point: 214.6 °C
• PSA: 6.48000
• Density: 1.07 g/cm³
• LogP: 4.99880
• Storage Temp.: Refrigerator, under inert atmosphere
• Sensitive.: Air Sensitive
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
• Water Solubility.: Soluble in water (<0.1 mg/ml), chloroform, benzene, ethyl ether, ethanol and toluene.
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 330.209598838
• Heavy Atom Count: 25
• Complexity: 342

Purity/Quality:

98%,99%, ^*data from raw suppliers

Leucomalachite green ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn; Xi; N
• Hazard Codes: Xn,N,Xi
• Statements: 40-50/53-22-36/37/38
• Safety Statements: 36/37-61-60-36/37/39-27-26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Dyes -> Di- and Triaryl Dyes
• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(C2=CC=CC=C2)C3=CC=C(C=C3)N(C)C
• Uses: A metabolite of Malachite Green For directly dyeing silk, wool, jute and leather; dyeing cotton after mordanting. Biological stain. Clinical reagent (inorganic phosphate assay). As spot test reagent for detecting sulfurous acid and cerium. As acid-base indicator: pH 0.0 yellow, 2.0 green; 11.6 green, 14 colorless. Leucomalachite Green is a reagent for the quantitative colorimetric micro determination of hemoglobin and other heme compounds.

Technology Process of Leucomalachite green

There total 64 articles about Leucomalachite green which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,4'-(phenylmethylene)bismorpholine (6425-08-7) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis(4-dimethylaminophenyl)phenylmethane (129-73-7)

Guidance literature:

With acetic acid; at 100 ℃; for 1h;

Reference yield: 89.0%

benzaldehyde (100-52-7) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis(4-dimethylaminophenyl)phenylmethane (129-73-7)

Guidance literature:

With 3-methyl-1-(4-sulfobutyl)imidazol-3-ium bis((trifluoromethyl)sulfonyl)azanide; In neat (no solvent); at 80 ℃; for 12h;

DOI:10.1039/d1ra03724b

Reference yield: 88.0%

malachit green (10309-95-2,14426-28-9) → bis(4-dimethylaminophenyl)phenylmethane (129-73-7)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 1h; Heating;

DOI:10.1021/tx0256679

upstream raw materials:

formic acid

1,1-bis(4-dimethylaminophenyl)-1-phenyl-methanol

sodium formate

2-(4,4'-bis-dimethylamino-benzhydryl)-benzoic acid

Downstream raw materials:

N,N-dimethyl-4-(phenylmethyl)benzenamine

N,N-dimethyl-aniline

1,1-bis(4-dimethylaminophenyl)-1-phenyl-methanol

4-(4,4'-bis-dimethylamino-α-hydroxy-benzhydryl)-benzenesulfonic acid

Refernces

• 1、 Nencki. "-". . p. 1148. Retrieved 1888.
• 2、 Jaratjaroonphong, Jaray,Saeeng, Rungnapha,Senapak, Warapong,Sirion, Uthaiwan,ponpao, nipaphorn. "Metal- And solvent-free synthesis of aniline- And phenol-based triarylmethanes: Via Br?nsted acidic ionic liquid catalyzed Friedel-Crafts reaction". . p. 22692 - 22709. Retrieved 2021/07/21.
• 3、 Gong, Bozhen,Hu, Zhiyu,Jiang, Guofang,Le, Zhanggao,Xie, Zongbo,Zhu, Zhiqiang. "Synthesis of Mannich-type derivatives from amides activated by hydrogen bonding with ZnCl2". supporting information. p. 9095 - 9099. Retrieved 2020/11/30.