Methylcysteine

Base Information

• Chemical Name: Methylcysteine
• CAS No.: 7728-98-5
• Molecular Formula: C₄H₉NO₂S
• Molecular Weight: 135.187
• European Community (EC) Number: 243-203-1
• NSC Number: 15387
• Nikkaji Number: J1.330.311H
• Wikidata: Q105111377
• Mol file: 7728-98-5.mol

Synonyms:7728-98-5;Methylcysteine;S-Methyl-DL-cysteine;H-DL-Cys(Me)-OH;19651-44-6;2-amino-3-methylsulfanylpropanoic acid;2-amino-3-(methylsulfanyl)propanoic acid;H-D-HoCys-OH;S-Methyl-D-Cys-OH;(R)-2-Amino-3-methylmercaptopropionic acid;2-amino-3-(methylthio)propanoic acid;USAF CB-24;DL-S-Methylcysteine;EINECS 243-203-1;NSC-15387;Methylcysteine #;S-Methyl cysteine;D0CU4Q;SCHEMBL110459;IDIDJDIHTAOVLG-UHFFFAOYSA-;NSC15387;2-amino-3-(methylthio)propanoicacid;STL572703;AKOS000197034;AKOS022154885;SB75603;2-amino-3-methylsulfanyl-propanoic acid;FT-0633434;FT-0693934;EN300-49161;AO-800/41069568;F8882-4377;Z317025996;4346186C-81BE-40FB-9500-D3D9BF817752

Chemical Property of Methylcysteine

Chemical Property:

• Vapor Pressure: 0.000267mmHg at 25°C
• Melting Point: 205-207 °C
• Refractive Index: 1.539
• Boiling Point: 300.3 °C at 760 mmHg
• PKA: 2.07±0.10(Predicted)
• Flash Point: 135.4 °C
• PSA: 88.62000
• Density: 1.26 g/cm³
• LogP: 0.46160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 135.03539970
• Heavy Atom Count: 8
• Complexity: 86.1

Purity/Quality:

99% ^*data from raw suppliers

S-Methyl-L-cysteine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCC(C(=O)O)N

Technology Process of Methylcysteine

There total 42 articles about Methylcysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dodecyl-dimethylsulphonium iodide (18412-81-2) + phenol (108-95-2,27073-41-2) → S-methyl-L-cysteine (1187-84-4,7728-98-5) + methoxybenzene (100-66-3)

Guidance literature:

With potassium hydroxide; In water; at 70 ℃; for 5h; pH = 9;

DOI:10.1039/P19830001941

Reference yield: 95.0%

hexadecyl-dimethylsulphonium iodide (64969-77-3) + (+/-)-thymidine (50-89-5,3424-98-4,4449-43-8,4781-17-3,16053-52-4,36646-86-3,39131-66-3,68224-82-8,128112-70-9,131682-41-2,137121-87-0,28854-96-8,3545-96-8,50-88-4) → S-methyl-L-cysteine (1187-84-4,7728-98-5) + 3-methylthymidine (958-74-7,115082-30-9)

Guidance literature:

With potassium hydroxide; In water; at 70 ℃; for 6h; pH = 11;

DOI:10.1039/P19830001941

Reference yield: 93.0%

L-Cysteine (52-90-4) + methyl iodide (74-88-4) → S-methyl-L-cysteine (1187-84-4,7728-98-5)

Guidance literature:

With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.08.097

upstream raw materials:

S-methyl-DL-cysteine

methylthiol

D-cysteine

(S)-3-chloroalanine

Downstream raw materials:

s-methyl-s-cysteine

N-benzoyl-S-methyl-L-cysteine

Methionin-ethylester

N-(2-benzylthio-2-methylpropanoyl)-S-methyl-L-cysteine

Refernces

• 1、 Kolodiazhna, Anastasy О.,Skliarov, Аleksei I.,Slastennikova, Alena A.,Kolodiazhnyi, Oleg I.. "Asymmetric synthesis of (S,R)- and (R,R)-methiin stereoisomers". . p. 713 - 717. Retrieved 2020/05/11.
• 2、 -. "Composition for promoting differentiation of skin keratinocyte comprising a SAC derivatives or a SMC derivatives". Paragraph 0057-0060; 0062-0064; 0111-0114; 0116-0118; 0161. . Retrieved 2021/02/02.