3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde

Base Information

• Chemical Name: 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde
• CAS No.: 153748-36-8
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.37
• Mol file: 153748-36-8.mol

Synonyms:3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde

Chemical Property of 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde

There total 4 articles about 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-6-methylpicolinaldehyde (66497-42-5) + 1-iodo-4-(4-methoxyphenyl)butane (73515-08-9) → 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde (153748-36-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h;

DOI:10.1021/jm00046a017

Reference yield:

3-hydroxy-6-methylpicolinaldehyde (66497-42-5) + potassium carbonate (584-08-7) + 1-iodo-4-(4-methoxyphenyl)butane (73515-08-9) → 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde (153748-36-8)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield:

3-hydroxy-2-hydroxymethyl-6-methylpyridine (42097-42-7) → 3-[4-(4-Methoxyphenyl)butyloxy]-6-methyl-2-pyridine carboxaldehyde (153748-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: MnO₂ / CH₂Cl₂ / 6 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

With manganese(IV) oxide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00046a017

upstream raw materials:

3-hydroxy-6-methylpicolinaldehyde

1-iodo-4-(4-methoxyphenyl)butane

3-hydroxy-2-hydroxymethyl-6-methylpyridine

4-(4-methoxyphenyl)butan-1-ol

Downstream raw materials:

3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

3-{6-((E)-2-Methoxycarbonyl-vinyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

3-{6-Hydroxymethyl-3-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-yl}-propionic acid methyl ester

(E)-3-{3-[4-(4-Methoxy-phenyl)-butoxy]-6-methyl-1-oxy-pyridin-2-yl}-acrylic acid methyl ester

Refernces

• 1、 -. "PHARMACEUTICAL PYRIDINE COMPOUNDS". . . Retrieved 2008/06/13.