2-(naphthalen-2-yl)-N-phenylacetamide

Base Information

• Chemical Name: 2-(naphthalen-2-yl)-N-phenylacetamide
• CAS No.: 955819-30-4
• Molecular Formula: C₁₈H₁₅NO
• Molecular Weight: 261.323
• Mol file: 955819-30-4.mol

Synonyms:2-(naphthalen-2-yl)-N-phenylacetamide

Chemical Property of 2-(naphthalen-2-yl)-N-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(naphthalen-2-yl)-N-phenylacetamide

There total 5 articles about 2-(naphthalen-2-yl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

aniline (62-53-3) + 2-naphthylacetic acid (581-96-4) → 2-(naphthalen-2-yl)-N-phenylacetamide (955819-30-4)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; 4,6-dithiocyano-5-nitropyrimidine; In acetonitrile; at 20 ℃; for 0.0166667h;

DOI:10.1021/acs.orglett.1c04258

Reference yield: 80.0%

2-naphthaldehyde tosylhydrazone (19350-74-4) + carbon monoxide (201230-82-2) + aniline (62-53-3) → 2-(naphthalen-2-yl)-N-phenylacetamide (955819-30-4)

Guidance literature:

2-naphthaldehyde tosylhydrazone; With sodium hydride; In toluene; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

carbon monoxide; aniline; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Aliquat (at)366; potassium carbonate; In toluene; mineral oil; at 60 ℃; for 23h; under 760.051 Torr;

DOI:10.1021/ja107351d

Reference yield: 77.0%

carbon monoxide (201230-82-2) + C18H15N2O2S(1-)*Na(1+) + aniline (62-53-3) → 2-(naphthalen-2-yl)-N-phenylacetamide (955819-30-4)

Guidance literature:

With potassium phosphate; cobalt(II) 5,10,15,20-tetraphenylporphyrin; In toluene; at 50 ℃; for 18h; under 7500.75 Torr; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201301731

upstream raw materials:

aniline

2-naphthylacetic acid

2-naphthaldehyde tosylhydrazone

carbon monoxide

Downstream raw materials:

N-(2-(2-naphthyl)ethyl)aniline

Refernces

• 1、 Yu, Weijie,Yang, Shuwu,Xiong, Fei,Fan, Tianxiang,Feng, Yan,Huang, Yuanyuan,Fu, Junkai,Wang, Tao. "Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation". . p. 3099 - 3103. Retrieved 2018/05/22.
• 2、 Zhang, Zhenhua,Liu, Yiyang,Ling, Lin,Li, Yuxue,Dong, Yian,Gong, Mingxing,Zhao, Xiaokun,Zhang, Yan,Wang, Jianbo. "Pd-catalyzed carbonylation of diazo compounds at atmospheric pressure: A catalytic approach to ketenes". supporting information; experimental part. p. 4330 - 4341. Retrieved 2011/06/21.