3-<3,4-dimethoxyphenyl>-2-oxo propanol

Base Information

• Chemical Name: 3-<3,4-dimethoxyphenyl>-2-oxo propanol
• CAS No.: 78886-14-3
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol file: 78886-14-3.mol

Synonyms:3-<3,4-dimethoxyphenyl>-2-oxo propanol

Chemical Property of 3-<3,4-dimethoxyphenyl>-2-oxo propanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-<3,4-dimethoxyphenyl>-2-oxo propanol

There total 14 articles about 3-<3,4-dimethoxyphenyl>-2-oxo propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Z-2-<3,4-dimethoxyphenyl>-1-tert-butyldiphenylsilyloxy methyl propenoate (232266-93-2) → 3-<3,4-dimethoxyphenyl>-2-oxo propanol (78886-14-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -100 - -15 ℃;

DOI:10.1016/S0040-4020(99)00317-8

Reference yield: 85.0%

Z-2-<3,4-dimethoxyphenyl>-1-tert-butyldimethylsilyloxy methyl propenoate (232266-92-1) → 3-<3,4-dimethoxyphenyl>-2-oxo propanol (78886-14-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0040-4020(99)00317-8

Reference yield: 83.0%

Z-2-<3,4-dimethoxyphenyl>-1-tert-butyldimethylsilyloxy ethyl propenoate (232266-96-5) → 3-<3,4-dimethoxyphenyl>-2-oxo propanol (78886-14-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -100 - -5 ℃;

DOI:10.1016/S0040-4020(99)00317-8

upstream raw materials:

diazomethane

3,4-dimethoxyphenylacetyl chloride

erythro-1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

(1RS,2RS)-1-(3,4-dimethoxy-phenyl)-propane-1,2,3-triol

Downstream raw materials:

1-ethoxy-1-(3,4-dimethoxy-phenyl)-acetone

3-(3,4-dimethoxyphenyl)propane-1,2-diol

Refernces

• 1、 Dalla,Catteau. "Chemocontrolled reduction of α-keto esters by hydrides: A possible solution for selective reduction of the ester function". . p. 6497 - 6510. Retrieved 2007/10/03.