(-) Cis 2-isopropyl cyclohexanol

Base Information

• Chemical Name: (-) Cis 2-isopropyl cyclohexanol
• CAS No.: 98102-90-0
• Molecular Formula: C₉H₁₈O
• Molecular Weight: 142.241
• Mol file: 98102-90-0.mol

Synonyms:(-) Cis 2-isopropyl cyclohexanol

Chemical Property of (-) Cis 2-isopropyl cyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-) Cis 2-isopropyl cyclohexanol

There total 19 articles about (-) Cis 2-isopropyl cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-isopropylcyclohexanone (1004-77-9) → (-) Cis 2-isopropyl cyclohexanol (98102-90-0) + (S)-2-isopropylcyclohexanone

Guidance literature:

With hydrogen; trans-RuH(η1-BH4)[(S)-xylbinap][(R,R)-dpen]; In isopropyl alcohol; for 2h; under 6080.41 Torr; Product distribution / selectivity;

Reference yield:

(1-methylethyl)-cyclohexane (696-29-7) → 2-cyclohexyl-2-propanol (16664-07-6) + 1-isopropyl-cyclohexanol (3552-01-0) + cis-(1S,2S)-2-isopropylcyclohexan-1-ol (98102-92-2) + 3-isopropyl-1-cyclohexanol (4534-77-4) + 4-isopropylcyclohexanol (4621-04-9) + (-) Cis 2-isopropyl cyclohexanol (98102-90-0)

Guidance literature:

With D-Glucose; nicotinamide adenine dinucleotide phosphate; lysozyme; DNase I; In aq. phosphate buffer; at 25 ℃; for 20h; pH=7.4; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/anie.201310892

Reference yield:

trans-2-isopropyl-cyclohex-3-enol → (+/-)-trans-2-Isopropyl-cyclohexanol (96-07-1,10488-23-0,10488-25-2,64823-98-9,98043-34-6,98102-89-7,98102-90-0,98102-91-1,98102-92-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

upstream raw materials:

2-isopropylcyclohexanone

cis-2-isopropylcyclohexan-1-ol

(1-methylethyl)-cyclohexane

aluminum isopropoxide

Downstream raw materials:

cis-2-isopropylcyclohexan-1-ol

(-) Trans 2-isopropyl cyclohexanol

(R)-2-isopropylcyclohexanone

(R)(+)-1r-Isopropyl-cyclohexanol-(2t)

Refernces

• 1、 Roiban, Gheorghe-Doru,Agudo, Ruben,Reetz, Manfred T.. "Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C-H activation step". supporting information. p. 8659 - 8663. Retrieved 2014/08/18.
• 2、 Ohkuma, Takeshi,Koizumi, Masatoshi,Muniz, Kilian,Hilt, Gerhard,Kabuto, Chizuko,Noyori, Ryoji. "trans-RuH(η1-BH4)(binap)(1,2-diamine): A catalyst for asymmetric hydrogenation of simple ketones under base-free conditions". . p. 6508 - 6509. Retrieved 2007/10/03.