((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Base Information Edit

Chemical Name:((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol
CAS No.:1369767-20-3
Molecular Formula:C₁₁H₁₃FO₂
Molecular Weight:196.221
Hs Code.:
Mol file:1369767-20-3.mol

Synonyms:((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Suppliers and Price of ((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of ((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol Edit

Chemical Property:

Boiling Point:327.5±17.0 °C(Predicted)
Density:1.248±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of ((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

There total 4 articles about ((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 528587-70-4
(1S,5R)-2-oxo-1-(3-fluorophenyl)-3-oxabicyclo[3.1.0]hexane

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b00217

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / Cooling with ice-salt

1.2: 16 h / 0 - 35 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 65 h / 0 - 35 °C

2.2: Cooling with ice

With sodium tetrahydroborate; sodium hexamethyldisilazane; In tetrahydrofuran; methanol;

Reference yield:

: 1450905-00-6
(1S,2R)-1-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

: 1369767-20-3
((1S,2R)-1-(3-fluorophenyl)cyclopropane-1,2-diyl)dimethanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 2 h / 60 °C

2: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;