Multi-step reaction with 9 steps
1.1: hydrogenchloride / ethanol; water / 2 h / 60 °C
2.1: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere
3.1: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction
4.1: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere
5.1: caesium carbonate / acetonitrile / 65 - 70 °C / Inert atmosphere
6.1: water; sodium hydroxide / acetonitrile / 20 - 25 °C
7.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / toluene; aq. phosphate buffer / 2 h / 0 - 20 °C / pH 7
8.1: hydrogenchloride; sodium chlorite / water; toluene; aq. phosphate buffer / 4 h / 26 °C
8.2: 0.33 h / 20 °C
8.3: 4 h / 80 °C / pH 13
9.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 15 °C / Inert atmosphere
9.2: 0 - 25 °C
With
pyridine; hydrogenchloride; sodium hypochlorite; sodium chlorite; lithium borohydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; aq. phosphate buffer; ethanol; water; ethyl acetate; toluene; acetonitrile;