6-(Trifluoromethyl)nicotinic acid

Base Information Edit

Chemical Name:6-(Trifluoromethyl)nicotinic acid
CAS No.:231291-22-8
Molecular Formula:C7H4 F3 N O2
Molecular Weight:191.109
Hs Code.:29333990
European Community (EC) Number:624-411-5
NSC Number:727682
DSSTox Substance ID:DTXSID20380558
Nikkaji Number:J2.008.066C
Wikidata:Q72512124
Mol file:231291-22-8.mol

Synonyms:6-(Trifluoromethyl)nicotinic acid;231291-22-8;6-(Trifluoromethyl)pyridine-3-carboxylic acid;6-Trifluoromethylnicotinic acid;6-Trifluoromethyl-nicotinic acid;3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-;2-Trifluoromethyl-5-pyridinecarboxylic acid;MFCD00792430;6-trifluoromethyl nicotinic acid;2-(trifluoromethyl)pyridine-5-carboxylic acid;6-trifluoromethyl-3-pyridinecarboxylic acid;6-(Trifluoromethyl)-3-pyridinecarboxylic Acid;6-(Trifluoromethyl)nicotinicacid;6-Trifluoromethyl;6-trifluormethylnicotinic acid;SCHEMBL186213;DTXSID20380558;JNYLMODTPLSLIF-UHFFFAOYSA-O;YTCFPYOGQUCNEX-UHFFFAOYSA-N;BCP22794;BBL101352;GEO-02388;NSC727682;STL555148;AKOS000117978;AB07094;AC-2460;BCP9000188;CS-W009256;FA-0727;NSC-727682;NCGC00336474-01;SY001329;AM20050975;FT-0644075;T2203;EN300-27607;A23984;AB01330972-02;6-(Trifluoromethyl)pyridine-3-carboxylic acid, 96%;W-200240;F2191-0125;Z235344877

Suppliers and Price of 6-(Trifluoromethyl)nicotinic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(Trifluoromethyl)nicotinic Acid
25g
$ 85.00

TRC
6-(Trifluoromethyl)nicotinic Acid
10g
$ 45.00

TCI Chemical
6-(Trifluoromethyl)nicotinic Acid >98.0%(GC)
1g
$ 29.00

TCI Chemical
6-(Trifluoromethyl)nicotinic Acid >98.0%(GC)
5g
$ 110.00

SynQuest Laboratories
6-(Trifluoromethyl)-3-pyridinecarboxylic acid 98%
5 g
$ 98.00

SynQuest Laboratories
6-(Trifluoromethyl)-3-pyridinecarboxylic acid 98%
1 g
$ 49.00

Oakwood
6-(Trifluoromethyl)nicotinic Acid 97%
5g
$ 60.00

Oakwood
6-(Trifluoromethyl)nicotinic Acid 97%
1g
$ 10.00

Matrix Scientific
6-(Trifluoromethyl)nicotinic acid 98%
5g
$ 34.00

Matrix Scientific
6-(Trifluoromethyl)nicotinic acid 98%
1g
$ 10.00

Total 162 raw suppliers

Chemical Property of 6-(Trifluoromethyl)nicotinic acid Edit

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:0.007mmHg at 25°C
Melting Point:193-197 °C(lit.)
Refractive Index:1.475
Boiling Point:259.322 °C at 760 mmHg
PKA:2.96±0.10(Predicted)
Flash Point:110.634 °C
PSA：50.19000
Density:1.485 g/cm³
LogP:1.79860
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:Acetonitrile (Slightly), Methanol (Slightly)
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:191.01941286
Heavy Atom Count:13
Complexity:204

Purity/Quality:

99% ^*data from raw suppliers

6-(Trifluoromethyl)nicotinic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CC(=NC=C1C(=O)O)C(F)(F)F
Physical properties 6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.
Uses 6-Trifluoromethyl Nicotinic Acid can be prepared to use Raf inhibitors to treat cancer.

Technology Process of 6-(Trifluoromethyl)nicotinic acid

There total 9 articles about 6-(Trifluoromethyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%