Technology Process of 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one
There total 5 articles about 5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: 0 - 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C
3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere
5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 2068.65 Torr
With
hydrogen; potassium acetate; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C
2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / isopropyl alcohol; toluene; water / 80 °C / Inert atmosphere
4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 2068.65 Torr
With
hydrogen; potassium acetate; sodium carbonate; caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
3: Suzuki Coupling;