3-hydroxy-5-iodobenzoic acid

Base Information

• Chemical Name: 3-hydroxy-5-iodobenzoic acid
• CAS No.: 50765-21-4
• Molecular Formula: C7H5IO3
• Molecular Weight: 264.019
• Mol file: 50765-21-4.mol

Synonyms:LogP

Chemical Property of 3-hydroxy-5-iodobenzoic acid

Chemical Property:

• Vapor Pressure: 3.19E-08mmHg at 25°C
• Refractive Index: 1.712
• Boiling Point: 431.8 °C at 760 mmHg
• PKA: 3.73±0.10(Predicted)
• Flash Point: 214.9 °C
• PSA: 57.53000
• Density: 2.155 g/cm³
• LogP: 1.69500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-5-iodobenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-5-iodobenzoic acid

There total 3 articles about 3-hydroxy-5-iodobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-5-nitro-benzoic acid (6313-17-3) → 3-hydroxy-5-iodobenzoic acid (50765-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) SOCl₂, (ii) /BRN= 1098229/

2: SnCl₂, aq. HCl

3: (i) aq. NaNO₂, H₂SO₄, (ii) aq. H₂SO₄

With hydrogenchloride; tin(ll) chloride;

DOI:10.1021/jm00264a023

Reference yield:

methyl 3-iodo-5-nitrobenzoate (50765-19-0) → 3-hydroxy-5-iodobenzoic acid (50765-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂, aq. HCl

2: (i) aq. NaNO₂, H₂SO₄, (ii) aq. H₂SO₄

With hydrogenchloride; tin(ll) chloride;

DOI:10.1021/jm00264a023

Reference yield:

methyl 3-amino-5-iodobenzoate (217314-45-9) → 3-hydroxy-5-iodobenzoic acid (50765-21-4)

Guidance literature:

Multistep reaction; (i) aq. NaNO₂, H₂SO₄, (ii) aq. H₂SO₄;

DOI:10.1021/jm00264a023

upstream raw materials:

methyl 3-amino-5-iodobenzoate

3-iodo-5-nitro-benzoic acid

methyl 3-iodo-5-nitrobenzoate

Downstream raw materials:

3-Hydroxy-5-iodbenzylalkohol

methyl 3-hydroxy-5-iodobenzoate

5-methyl-2-(3-(4-(methylsulfonyl)phenoxy)-5-(pyrrolidine-1-carbonyl)phenyl)pyrimidin-4(3H)-one

(3-(4-(benzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenyl)(pyrrolidin-1-yl)methanone