ethyl 2-methyl-4-phenyl butyrate

Base Information

• Chemical Name: ethyl 2-methyl-4-phenyl butyrate
• CAS No.: 14307-99-4
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 14307-99-4.mol

Synonyms:ethyl 2-methyl-4-phenyl butyrate

Chemical Property of ethyl 2-methyl-4-phenyl butyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-4-phenyl butyrate

There total 11 articles about ethyl 2-methyl-4-phenyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 4-((4-methoxyphenyl)amino)-2-methylene-4-phenylbutanoate → ethyl 2-methyl-4-phenyl butyrate (14307-99-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; for 5h;

DOI:10.1039/c6cc09172e

Reference yield: 62.0%

ethyl 2-diethoxyphosphorylpropionate (3699-66-9) + phenylacetaldehyde (122-78-1) → ethyl 2-methyl-4-phenyl butyrate (14307-99-4)

Guidance literature:

With lithium methanolate; ammonia; lithium perchlorate; In N,N-dimethyl-formamide; at 20 ℃; for 8h; Electrochemical reaction;

DOI:10.1021/acs.joc.1c01024

Reference yield: 27.0%

benzaldehyde, hydrazone (5281-18-5) + methyl methacrylate (97-63-2,9003-42-3) → ethyl 2-methyl-4-phenyl butyrate (14307-99-4)

Guidance literature:

With potassium phosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1,2-bis(dimethylphosphanyl)ethane; cesium fluoride; at 50 ℃; for 5h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/anie.201700059

upstream raw materials:

2,2-diethoxy-3-methyl-5-phenyl-2,3-dihydro-furan

methyl methacrylate

benzyl chloride

ethanol

Downstream raw materials:

2-ethyl-2-methyl-4-phenyl-butyric acid

2-methyl-1-tetralone

2-methyl-4-phenylbutan-1-ol

1,1,4-triphenyl-2-methyl-1-butanol

Refernces

• 1、 Zhang, Xiaofeng,Jiang, Runze,Cheng, Xu. "Electrochemical Tandem Olefination and Hydrogenation Reaction with Ammonia". . p. 16016 - 16025. Retrieved 2021/08/24.
• 2、 Amézquita-Valencia, Manuel,Alper, Howard. "Regioselective Alkoxycarbonylation of Allyl Phenyl Ethers Catalyzed by Pd/dppb under Syngas Conditions". . p. 3860 - 3867. Retrieved 2016/05/24.