5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

Base Information

• Chemical Name: 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER
• CAS No.: 15911-11-2
• Molecular Formula: C9H11 N O4
• Molecular Weight: 197.191
• Hs Code.: 2934999090
• Mol file: 15911-11-2.mol

Synonyms:4-Acetyl-5-methyl-3-isoxazolecarboxylicacid ethyl ester

Chemical Property of 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

Chemical Property:

• Vapor Pressure: 8.91E-05mmHg at 25°C
• Boiling Point: 339.9°Cat760mmHg
• Flash Point: 159.4°C
• PSA: 69.40000
• Density: 1.176g/cm³
• LogP: 1.36230

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-Acetyl-5-methylisoxazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Harmful:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER

There total 6 articles about 5-ETHYL-ISOXAZOLE-3,4-DICARBOXYLIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester (216962-12-8) → ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate (15911-11-2)

Guidance literature:

With toluene-4-sulfonic acid; In acetone;

DOI:10.1016/S0040-4039(98)01782-1

Reference yield: 83.0%

ethyl 2-chloro-2-(hydroxyimino)acetate (14337-43-0) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate (15911-11-2)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1016/S0040-4020(01)00781-5

Reference yield: 49.0%

ethyl chlorooximidoacetate (95080-93-6) + acetylacetone (123-54-6,81235-32-7) → ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate (15911-11-2)

Guidance literature:

With ethanol; sodium; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.08.080

upstream raw materials:

sodium (Z)-4-oxopent-2-en-2-olate

ethyl 2-chloro-2-(hydroxyimino)acetate

3-isoxazolecarboxylic acid 5-methyl-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-ethyl ester

acetylacetone

Downstream raw materials:

5-methyl-4-[1-(phenyl-hydrazono)-ethyl]-isoxazole-3-carboxylic acid ethyl ester

3,4-dimethyl-6-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one

6-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-3,4-dimethyl-6H-isoxazolo[3,4-d]pyridazin-7-one

4-amino-2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-(1-hydroxyethyl)-6-methylpyridazin-3(2H)-one

Refernces

• 1、 McDaniel, Steven W.,Keyari, Charles M.,Rider, Kevin C.,Natale, Nicholas R.,Diaz, Philippe. "Suzuki-Miyaura cross-coupling of benzylic bromides under microwave conditions". supporting information; experimental part. p. 5656 - 5658. Retrieved 2011/11/06.
• 2、 Burkhart, David J.,McKenzie, Andrew R.,Nelson, Jared K.,Myers, Katherine I.,Zhao, Xue,Magnusson, Kathy R.,Natale, Nicholas R.. "Catalytic asymmetric synthesis of glutamate analogues". . p. 1285 - 1288. Retrieved 2007/10/03.