14337-43-0 Usage
Description
2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER is an off-white solid that serves as an essential intermediate in the synthesis of various organic compounds and pharmaceuticals. It is characterized by its unique chemical structure, which allows it to participate in multiple chemical reactions and contribute to the formation of complex molecules.
Uses
Used in Pharmaceutical Industry:
2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER is used as a synthetic intermediate for the preparation of (+)-and (?)-Δ2-isoxazolines, which are important compounds in the development of pharmaceuticals with potential therapeutic applications.
Used in Chiral Amino Acid Synthesis:
In the pharmaceutical industry, 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER is also used as a key component in the synthesis of CIP-AS (?), a chiral amino acid structurally related to glutamic acid. This chiral amino acid has the potential to act as an agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptors, which are involved in various neurological processes.
Used in Organic Chemistry:
2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER is used as a reagent to generate ethoxycarbonylformonitrile oxide in situ by treatment with sodium bicarbonate. This reaction is crucial in the synthesis of various organic compounds and contributes to the development of new materials and chemicals.
Used in the Preparation of Dihydro-oxadiazines:
In the field of organic chemistry, 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER is used to prepare N-azirdinyloximes, which, upon treatment with scandium triflate (418218), provide dihydro-oxadiazines. These compounds have potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 14337-43-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,3,3 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 14337-43:
(7*1)+(6*4)+(5*3)+(4*3)+(3*7)+(2*4)+(1*3)=90
90 % 10 = 0
So 14337-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H6ClNO3/c1-2-9-4(7)3(5)6-8/h8H,2H2,1H3/b6-3+
14337-43-0Relevant articles and documents
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Rave,T.W.,Breslow,D.S.
, p. 3813 - 3815 (1971)
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Kissinger,Ungnade
, p. 1517 (1958)
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Synthesizing method of isoxadifen-ethyl for industrialized production
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Paragraph 0024; 0027; 0029; 0038, (2018/09/12)
The invention provides a synthesizing method of isoxadifen-ethyl for industrialized production. The synthesizing method comprises the following steps of using chlorobenzene as a raw material, using tetrahydrofuran as a solvent, and reacting with magnesium, so as to obtain a phenyl magnesium chloride Grignard reagent; performing nucleophilic addition reaction with acetophenone to generate 1,1-diphenylethanol; adding p-toluenesulfonic acid to dewater, so as to generate 1,1-diphenylethene; reacting with ethyl 2-chloro-2-(hydroxyimino)acetate, so as to generate an isoxadifen-ethyl product, whereinthe purity can reach 99%.
CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM
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Page/Page column 52, (2014/09/03)
In alternative embodiments, the invention provides nucleophilic hydroxyimino- acetamido alkylamine antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). The hydroxyimino-acetamido alkylamines of the invention are designed to fit within AChE active center gorge dimensions, bind with reasonable affinity, and react with the conjugated phosphate atom in the gorge. The hydroxyimino- acetamido alkylamines of the invention are also designed to possess ionization states that govern affinity and reactivity for the two linked hAChE re-activation steps. In alternative embodiments, the invention provides pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi- chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound of the invention.
