3209-70-9Relevant articles and documents
Ethyl 2-nitroacetate as a new synthetic equivalent of ethoxycarbonylnitrile oxide
Kislyi, V. P.,Laikhter, A. L.,Ugrak, B. I.,Semenov, V. V.
, p. 98 - 100 (1994)
It was shown that ethyl 2-nitroacetoacetate is a synthetic precursor of ethoxycarbonylnitrile oxide as well as of isoxazole- and isoxazoline-3-carboxylic acids and their esters.The elimination of acetic acid from ethyl 2-nitroacetoacetate occurs in a mixture of acetic acid and acetic anhydride in the presence of strong mineral acids, e.g., H2SO4, at room temperature and gives isoxazolines in yields of up to 85 - 91percent. - Key words: ethoxycarbonylnitrile oxide, isoxazoles, isoxazolines.
Ring-opening reactions of cyclopropanes. Part 8.1 Nitrosation of donor-acceptor cyclopropanes
Cermola, Flavio,Di Gioia, Lucrezia,Graziano, Maria Liliana,Iesce, Maria Rosaria
, p. 677 - 681 (2007/10/03)
The reaction of 2,2-dialkoxycyclopropane-1-carboxylates 1a-d and monoalkoxycyclopropane 1e with NOCl gives isoxazoline- and/or isoxazole-3-carboxylates by regioselective ring-opening at C1-C2 bond. A mechanistic interpretation suggests the intermediacy of well-stabilised dipolar species.
4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page 41, (2010/02/07)
3-Substituted pyrrolidines having a spiropiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
