N3-PEG1-CH2CH2NH2

Base Information

• Chemical Name: N3-PEG1-CH2CH2NH2
• CAS No.: 464190-91-8
• Molecular Formula: C₄H₁₀N₄O
• Molecular Weight: 130.15
• Mol file: 464190-91-8.mol

Synonyms:2-aminoethyl 2’-azidoethyl ether

Chemical Property of N3-PEG1-CH2CH2NH2

Chemical Property:

• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azido-PEG1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Azido-PEG1-amine is a heterobifunctional linker containing an amino(NH2)and an azide (N3) group. The amino group is reactive with carboxylic acids, activated NHS esters,. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Technology Process of N3-PEG1-CH2CH2NH2

There total 5 articles about N3-PEG1-CH2CH2NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,5-diazido-3-oxapentane (24345-74-2) → 2-aminoethyl 2’-azidoethyl ether (464190-91-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; diethyl ether; water; at 25 ℃;

DOI:10.1055/a-1509-5904

Reference yield: 90.0%

C4H9N6O → 2-aminoethyl 2’-azidoethyl ether (464190-91-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; diethyl ether; water; at 20 ℃;

Reference yield: 63.0%

C12H12N4O3 (1441062-11-8) → 2-aminoethyl 2’-azidoethyl ether (464190-91-8)

Guidance literature:

With methylamine; In ethanol; Reflux;

DOI:10.1142/S1088424612501350

upstream raw materials:

1-(2-(tert-Butoxycarbonylamino)ethoxy)-2-azidoethane

C₁₂H₁₂N₄O₃

1,5-diazido-3-oxapentane

trifluoroacetic acid

Downstream raw materials:

C₂₇H₃₃N₅O₄

Refernces

• 1、 Seggio, Mimimorena,Payamifar, Sara,Fraix, Aurore,Kalydi, Eszter,Kasal, Petr,Catanzano, Ovidio,Conte, Claudia,Quaglia, Fabiana,Sortino, Salvatore. "Visible light-activatable cyclodextrin-conjugates for the efficient delivery of nitric oxide with fluorescent reporter and their inclusion complexes with betaxolol". supporting information. p. 8449 - 8455. Retrieved 2021/05/26.
• 2、 -. "AGENTS AND METHODS FOR TREATING TAUOPATHIES". Page/Page column 38; 39. . Retrieved 2021/12/08.