1,5-Diazido-3-oxapentane

Base Information

• Chemical Name: 1,5-Diazido-3-oxapentane
• CAS No.: 24345-74-2
• Molecular Formula: C4H8 N6 O
• Molecular Weight: 156.147
• Hs Code.: 2929909090
• DSSTox Substance ID: DTXSID90444939
• Nikkaji Number: J2.901.318G
• Wikidata: Q82263224
• Mol file: 24345-74-2.mol

Synonyms:Azido-PEG1-Azide;24345-74-2;1,5-DIAZIDO-3-OXAPENTANE;1-azido-2-(2-azidoethoxy)ethane;Ethane,1,1'-oxybis[2-azido-;Bis(2-azidoethyl)ether;Azido-PEG1-Azido;N3-PEG1-N3;Bis(2-azidoethyl) ether;LCZC1250;SCHEMBL13469149;DTXSID90444939;Azide-PEG-Azide, MW 1,000;Azide-PEG-Azide, MW 2,000;Azide-PEG-Azide, MW 3,400;Azide-PEG-Azide, MW 5,000;Azide-PEG-Azide, MW 10,000;Azide-PEG-Azide, MW 20,000;AKOS030240484;GS-6055;BP-20908;BP-23446;BP-23447;BP-23449;BP-23451;BP-28680;BP-28681;HY-133390;CS-0116487;FT-0666427;D84710;J-015457

Chemical Property of 1,5-Diazido-3-oxapentane

Chemical Property:

• Melting Point: NA
• Boiling Point: 75 °C(Press: 2.5 Torr)
• PSA: 108.73000
• LogP: 0.52912
• Storage Temp.: -20°C Freezer
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 156.07595890
• Heavy Atom Count: 11
• Complexity: 159

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,5-Diazido-3-oxapentane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCN=[N+]=[N-])N=[N+]=[N-]
• Uses: Multifunctional alkylating agent

Technology Process of 1,5-Diazido-3-oxapentane

There total 7 articles about 1,5-Diazido-3-oxapentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethylene glycol ditosylate (7460-82-4) → 1,5-diazido-3-oxapentane (24345-74-2)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 5h;

DOI:10.1002/ejoc.201500997

Reference yield: 97.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) → 1,5-diazido-3-oxapentane (24345-74-2)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 10h;

DOI:10.1021/ja051685b

Reference yield: 93.0%

3-oxa-1,5-dichloropentane (111-44-4) → 1,5-diazido-3-oxapentane (24345-74-2)

Guidance literature:

With sodium azide; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 48h;

DOI:10.1021/acs.inorgchem.1c00152

upstream raw materials:

diethylene glycol ditosylate

3-oxa-1,5-dichloropentane

1,1'-oxybis(2-bromo-ethane)

diethylene glycol dimesylate

Downstream raw materials:

2-aminoethyl 2’-azidoethyl ether

4-phenyl-1-(2-(2-(4-phenyl-1,2,3-triazol-1-yl)ethoxy)ethyl)-1,2,3-triazole

C₁₁H₁₆N₂O₂

C₂₄H₂₈N₆O₃

Refernces

• 1、 Wharton, Luke,Kurakina, Elena,Radchenko, Valery,Schaffer, Paul,Orvig, Chris. "Chemical Promiscuity of Non-Macrocyclic Multidentate Chelating Ligands for Radiometal Ions: H4neunpa-NH2vs H4noneunpa". . p. 4076 - 4092. Retrieved 2021.
• 2、 Lang, Chao,Zhang, Xin,Luo, Quan,Dong, Zeyuan,Xu, Jiayun,Liu, Junqiu. "Powerful Bipodal Anion Transporters Based on Scaffolds That Contain Different Chalcogens". . p. 6458 - 6465. Retrieved 2015.
• 3、 Kwan, Chak-Shing,Chan, Albert S. C.,Leung, Ken Cham-Fai. "A Fluorescent and Switchable Rotaxane Dual Organocatalyst". . p. 976 - 979. Retrieved 2016.
• 4、 Niskanen, Jukka,Karesoja, Mikko,Aseyev, Vladimir,Qiu, Xing-Ping,Winnik, Franoise M.,Tenhu, Heikki. "Thermal response of a PVCL-HA conjugate". . p. 425 - 436. Retrieved 2016.
• 5、 Huang, Boxuan,Li, Weijia,Mu, Yu,Shao, Liang,Su, Yangqing,Sun, Mengsi,Xu, Huan,Yang, Fan,Yu, Fei,Zhang, Jihong,Zhang, Yuan. "Design and Synthesis of Oleanolic Acid Trimers to Enhance Inhibition of Influenza Virus Entry". . p. 1759 - 1765. Retrieved 2021/11/18.