2,5-Dimethoxy-4-ethylamphetamine

Base Information

• Chemical Name: 2,5-Dimethoxy-4-ethylamphetamine
• CAS No.: 22004-32-6
• Deprecated CAS: 41538-40-3
• Molecular Formula: C13H21 N O2
• Molecular Weight: 223.315
• Hs Code.: 2922299090
• UNII: 9SK6K682UL
• DSSTox Substance ID: DTXSID00860585
• Nikkaji Number: J71.136E
• Wikipedia: 2,5-Dimethoxy-4-ethylamphetamine
• Wikidata: Q947249
• Metabolomics Workbench ID: 146122
• ChEMBL ID: CHEMBL8224
• Mol file: 22004-32-6.mol

Synonyms:2,5-dimethoxy-4-ethylamphetamine;2,5-dimethoxy-4-ethylamphetamine, (+-)-isomer;2,5-dimethoxy-4-ethylamphetamine, (R)-isomer;2,5-dimethoxy-4-ethylamphetamine, (S)-isomer;2,5-dimethoxy-4-ethylamphetamine, hydrochloride;2,5-dimethoxy-4-ethylamphetamine, hydrochloride, (+-)-isomer;2,5-dimethoxy-4-ethylamphetamine, hydrochloride, (R)-isomer;2,5-dimethoxy-4-ethylamphetamine, hydrochloride, (S)-isomer

Chemical Property of 2,5-Dimethoxy-4-ethylamphetamine

Chemical Property:

• Boiling Point: 322.7°Cat760mmHg
• PKA: 9.77±0.10(Predicted)
• Flash Point: 162.9°C
• PSA: 44.48000
• Density: 0.998g/cm³
• LogP: 2.85620
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 223.157228913
• Heavy Atom Count: 16
• Complexity: 198

Purity/Quality:

99% ^*data from raw suppliers

DOETHCl(2,5-Dimethoxy-4-ethylamphetamineHCl) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1OC)CC(C)N)OC
• Uses: DOET is a potent, long-acting psychoactive drug of the phenethylamine and amphetamine chemical classes that, similar to other substituted amphetamines, likely acts as a serotonin 5-HT2 receptor partia l agonist. This compound is intended only for research and forensic applications.

Technology Process of 2,5-Dimethoxy-4-ethylamphetamine

There total 6 articles about 2,5-Dimethoxy-4-ethylamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Ethyl-2,5-dimethoxy-β-methyl-β-nitrostyrol (30431-62-0) → 2,5-dimethoxy-4-ethylamphetamine (22004-32-6)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jm00256a016

Reference yield:

ethylhydroquinone dimethyl ether (1199-08-2) → 2,5-dimethoxy-4-ethylamphetamine (22004-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃

2: NH₄OAc / acetic acid

3: LiAlH₄

With lithium aluminium tetrahydride; ammonium acetate; trichlorophosphate; In acetic acid;

DOI:10.1021/jm00256a016

Reference yield:

2,5-dimethoxy-4-ethylbenzaldehyde (50505-61-8) → 2,5-dimethoxy-4-ethylamphetamine (22004-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / acetic acid

2: LiAlH₄

With lithium aluminium tetrahydride; ammonium acetate; In acetic acid;

DOI:10.1021/jm00256a016

upstream raw materials:

4-Ethyl-2,5-dimethoxy-β-methyl-β-nitrostyrol

ethylhydroquinone dimethyl ether

2,5-dimethoxy-4-ethylbenzaldehyde

2',5'-dimethoxyacetophenone

Refernces

• 1、 Shulgin,Dyer. "Psychotomimetic phenylisopropylamines. 5. 4 alkyl 2,5 dimethoxyphenylisopropylamines". . p. 1201 - 1204. Retrieved 2007/10/06.