4-AMINO-1-(1-PROPYL)-PIPERIDINE

Base Information

• Chemical Name: 4-AMINO-1-(1-PROPYL)-PIPERIDINE
• CAS No.: 42389-59-3
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 29333990
• Mol file: 42389-59-3.mol

Synonyms:1-Propylpiperidin-4-amine;

Chemical Property of 4-AMINO-1-(1-PROPYL)-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.805mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 182.6 °C at 760 mmHg
• PKA: 10.52±0.20(Predicted)
• Flash Point: 63.2 °C
• PSA: 29.26000
• Density: 0.893 g/cm³
• LogP: 1.45770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

1-Propylpiperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

Useful:

Technology Process of 4-AMINO-1-(1-PROPYL)-PIPERIDINE

There total 5 articles about 4-AMINO-1-(1-PROPYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (1-propylpiperidin-4-yl)carbamate → 4-amino-1-propylpiperidine (42389-59-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 20h; under 760.051 Torr;

DOI:10.1016/j.ejmech.2017.03.013

Reference yield:

piperidin-4-ylcarbamic acid benzyl ester (182223-54-7) → 4-amino-1-propylpiperidine (42389-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / Reflux

2: hydrogen; palladium 10% on activated carbon / 20 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1016/j.ejmech.2017.03.013

Reference yield:

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine (220394-97-8) → 4-amino-1-propylpiperidine (42389-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / Reflux

3: hydrogen; palladium 10% on activated carbon / 20 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2017.03.013

upstream raw materials:

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine

1-(tert-butoxycarbonyl)-4-aminopiperidine

piperidin-4-ylcarbamic acid benzyl ester

Downstream raw materials:

C₁₆H₂₁ClFN₃O₂

Refernces