4-METHYL-2-MORPHOLINOQUINOLINE

Base Information

• Chemical Name: 4-METHYL-2-MORPHOLINOQUINOLINE
• CAS No.: 79140-31-1
• Molecular Formula: C₁₄H₁₆N₂O
• Molecular Weight: 228.294
• Mol file: 79140-31-1.mol

Synonyms:4-methyl-2-(4-morpholinyl)quinoline

Chemical Property of 4-METHYL-2-MORPHOLINOQUINOLINE

Chemical Property:

• Boiling Point: 181-182.5 °C(Press: 3.5 Torr)
• PKA: 6.87±0.61(Predicted)
• Density: 1.162±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-METHYL-2-MORPHOLINOQUINOLINE

There total 11 articles about 4-METHYL-2-MORPHOLINOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

morpholine (110-91-8,99108-56-2) + 2-chloro-4-methylquinoline (634-47-9) → 4-methyl-2-(4-morpholinyl)quinoline (79140-31-1)

Guidance literature:

With C₄₈H₅₆ClN₃Pd; potassium tert-butylate; In tetrahydrofuran; at 70 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/asia.201700877

Reference yield: 79.0%

4-(benzoyloxy)morpholine (5765-65-1) + 4-methylquinoline 1-oxide (4053-40-1) → 4-methyl-2-(4-morpholinyl)quinoline (79140-31-1)

Guidance literature:

With potassium carbonate; 1,2-dichloro-ethane; copper(l) chloride; at 80 ℃; for 10h; Sealed tube;

DOI:10.1002/ejoc.201800963

Reference yield: 68.0%

→ 4-methyl-2-(4-morpholinyl)quinoline (79140-31-1)

Guidance literature:

With tert.-butylhydroperoxide; copper(l) iodide; L-proline; In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

morpholine

2-chloro-4-methylquinoline

2-bromo-4-methyl-quinoline

4-methyl-morpholine

Refernces

• 1、 -. "Preparation method of quinoline derivative". Paragraph 0051; 0059; 0064. . Retrieved 2018/07/30.
• 2、 Deng, Qinyue,Zhang, Yang,Zhu, Haibo,Tu, Tao. "Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N-Heteroaryl Chlorides". supporting information. p. 2364 - 2368. Retrieved 2017/09/06.