Technology Process of 3-(4-chloro-2-methoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine
There total 6 articles about 3-(4-chloro-2-methoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-chloro-2-methoxy-N-(5-(4-methoxyphenyl)pyridin-2-yl)-benzohydrazide;
With
trichlorophosphate;
at 80 - 100 ℃;
With
sodium carbonate;
In
water;
pH=9;
- Guidance literature:
-
With
trichlorophosphate;
at 80 - 100 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 20 h / 100 °C / Inert atmosphere
2.1: hydrazine hydrate / 48 h / 20 - 100 °C
3.1: 4-methyl-morpholine; benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 20 °C / Inert atmosphere
4.1: trichlorophosphate / 80 - 100 °C
4.2: pH 9
With
4-methyl-morpholine; benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; potassium carbonate; hydrazine hydrate; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; dichloromethane; water;