diethyl 2-methyl-2-phenethylmalonate

Base Information

• Chemical Name: diethyl 2-methyl-2-phenethylmalonate
• CAS No.: 35205-59-5
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 35205-59-5.mol

Synonyms:diethyl 2-methyl-2-phenethylmalonate

Chemical Property of diethyl 2-methyl-2-phenethylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-methyl-2-phenethylmalonate

There total 8 articles about diethyl 2-methyl-2-phenethylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Bromo-2-phenylacetylene (932-87-6) → diethyl 2-methyl-2-phenethylmalonate (35205-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn

2: H₂ / Pd-CaCO₃

With hydrogen; zinc; Lindlar's catalyst;

Reference yield:

1-phenyl-2-bromoethane (103-63-9) + sodium diethyl methylmalonate → diethyl 2-methyl-2-phenethylmalonate (35205-59-5)

Guidance literature:

With xylene; at 150 - 160 ℃;

DOI:10.1021/ja01177a001

Reference yield:

1-phenyl-2-bromoethane (103-63-9) + Diethyl methylmalonate (609-08-5) → diethyl 2-methyl-2-phenethylmalonate (35205-59-5)

Guidance literature:

Multistep reaction; (i) Na, (ii) /BRN= 507487/;

upstream raw materials:

1-phenyl-2-bromoethane

diethyl 2-methyl-2-(phenylethynyl)malonate

Diethyl methylmalonate

diethyl 2-phenylcyclopropane-1,1-dicarboxylate

Downstream raw materials:

β-Phenaethyl-methyl-malonsaeure

2-methyl-4-phenylbutanoic acid

Refernces

• 1、 -. "Benzene compound and pharmaceutical use thereof". . . Retrieved 2008/06/13.