3,4-dihydro-8-methoxy-3-methylisocoumarin

Base Information

• Chemical Name: 3,4-dihydro-8-methoxy-3-methylisocoumarin
• CAS No.: 30407-92-2
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 30407-92-2.mol

Synonyms:3,4-dihydro-8-methoxy-3-methylisocoumarin

Chemical Property of 3,4-dihydro-8-methoxy-3-methylisocoumarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-8-methoxy-3-methylisocoumarin

There total 2 articles about 3,4-dihydro-8-methoxy-3-methylisocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 8-methoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one (16281-42-8,30407-92-2,76985-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: (S)-PhCH(Me)N(Li)(CH₂)3OMe / tetrahydrofuran / -78 °C

With (S)-PhCH(Me)N(Li)(CH₂)3OMe; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1039/c39830000764

Reference yield:

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 3,4-dihydro-8-methoxy-3-methylisocoumarin (30407-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: 52 percent / LDA / tetrahydrofuran / -78 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetone;

DOI:10.1039/c39830000764

Reference yield: 97.0%

8-methoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one (16281-42-8,30407-92-2,76985-75-6) → (R)-(-)-mellein (480-33-1,1200-93-7,17397-85-2,62623-84-1)

Guidance literature:

With hydrogen bromide; acetic acid; for 4h; Heating;

DOI:10.1016/S0957-4166(97)00217-6

upstream raw materials:

ethyl 2-hydroxy-6-methylbenzoate

Downstream raw materials:

2-methoxy-6-((E)-prop-1-enyl)benzoic acid

8-methoxy-3-methyl-1H-isochromen-1-one

(R)-(-)-mellein

8-benzoyloxy-3-methyl-isocoumarin

Refernces