Altrenogest

Base Information

• Chemical Name: Altrenogest
• CAS No.: 850-52-2
• Molecular Formula: C21H26O2
• Molecular Weight: 310.436
• Hs Code.: 2937290090
• European Community (EC) Number: 212-703-1
• UNII: 2U0X0JA2NB
• DSSTox Substance ID: DTXSID3048863
• Nikkaji Number: J71.378C
• Wikipedia: Altrenogest
• Wikidata: Q4736979
• NCI Thesaurus Code: C83529
• RXCUI: 1314612
• Metabolomics Workbench ID: 152582
• ChEMBL ID: CHEMBL1315492
• Mol file: 850-52-2.mol

Synonyms:17 alpha-allyl-17-beta-hydroxyestra-4,9,11-trien-3-one;17 alpha-allyl-estratriene 4,9,11,17 beta-ol-one;17-allyltrenbolone;allyl trenbolone;altrenogest;Regumate;Ru-2267

Chemical Property of Altrenogest

Chemical Property:

• Appearance/Colour: Slightly yellow powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 120oC
• Refractive Index: 1.594
• Boiling Point: 495.6 °C at 760 mmHg
• PKA: 14.59±0.40(Predicted)
• Flash Point: 210.1 °C
• PSA: 37.30000
• Density: 1.15 g/cm³
• LogP: 4.27560
• Storage Temp.: 0-6°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 310.193280068
• Heavy Atom Count: 23
• Complexity: 665

Purity/Quality:

99% ^*data from raw suppliers

Altrenogest ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2(CC=C)O
• Isomeric SMILES: C[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC=C)O
• Description: Altrenogest is used to suppress estrus in mares in order to facilitate induction of normal estrous cycle activity. It is also used in mares to synchronize scheduled breeding activity. In the suppression of estrous behavior in mares, this is usually related to mares that are used as performance horses.
• Uses: Altrenogest is used for suppression of estrus. The mare will experience a predictable occurrence of estrus following drug withdrawal. This allows a regular cycle during the transition from winter anestrus to the physiological breeding season in mares with active ovaries. By managing the reproductive cycle, horse owners have more control over breeding procedures and the timing of the arrival of foals. Altrenogest can be used as a synthetic progestational agent used in veterinary medicine for the control of estrus in mares and antineoplastic.

Technology Process of Altrenogest

There total 12 articles about Altrenogest which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

C24H36O2Si → Altrenogest (850-52-2)

Guidance literature:

With chloranil; In dichloromethane; at 20 ℃; for 1h; Time;

Reference yield: 75.8%

17β-hydroxy-17α-propenylestrone-3-one-5,10-diene (23760-34-1) → Altrenogest (850-52-2)

Guidance literature:

With chloranil; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 ℃; Reagent/catalyst; Temperature;

Reference yield: 65.0%

Trendione (4642-95-9) + allylmagnesium bromide (1730-25-2) → Altrenogest (850-52-2)

Guidance literature:

Trendione; With hydrogenchloride; In ethylene glycol; at 10 - 60 ℃; for 10h; Autoclave;

allylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 6h; Temperature; Solvent; Autoclave;

upstream raw materials:

ethylene deltenone

17β-hydroxy-17α-propenylestrone-3-one-5,10-diene

Trendione

allylmagnesium bromide

Refernces

• 1、 -. "Efficient synthesis method for altrenogest". . . Retrieved 2019/02/04.
• 2、 -. "Synthetic method of altrenogest". Paragraph 0031-0032; 0037-0038. . Retrieved 2017/09/01.